background: fragile histidine triad protein (fhit), as a known tumor suppressor protein, has been proposed to play crucial role in inhibiting p53 degradation by mdm2. studies have confirmed fhit interaction with p53 or mdm2, although functional interacting domains of fhit with mdm2 and/or p53 are not completely defined. thus, through determining the significant structural interacting domains of...

the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

Background: CDKN2A, encoding two important tumor suppressor proteins p16 and p14, is a tumor suppressor gene. Mutations in this gene and subsequently the defect in p16 and p14 proteins lead to the downregulation of RB1/p53 and cancer malignancy. To identify the structural and functional effects of mutations, various powerful bioinformatics tools are available. The aim of this study is the ident...

hypermethylation of cpg islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. klotho; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. recently the relevance ...

the p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms.the transcription factor p63 is a homologue of the tumor suppressor p53. unlike p53, which is dispensable for normal development, p63 is critical for the development of stratified epithelial tissues such as epidermis, breast, and prostate. p63, , is transcribed from two different promoters giving rise...

materials and methods twelve natural compounds jaceosidin, withaferin a, curcumin, epigallocatechin-3-gallate (egcg), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against e6 and e7 oncoproteins of high-risk hpv types 16 and 18 using a protein-ligand docking software called autodock4.2. results out of these 12 natural compo...

the p21 belongs to the cip/kip family of cdk inhibitors involved in cell cycle arrest at specific stages of the cell cycle progression. dna methylation is the best studied epigenetic mark that have been evidently associated to chromatin condensation, and repression of gene transcription. the cpg island hypermethylation in promoter region of certain genes occurs in cancer cells and affects tumor...

background colorectal cancer (crc) is the second most common malignancy in the world.  however, its mortality rate can be reduced if diagnosed early. p33 ing1b is a tumor suppressor protein, which plays a role in growth control and apoptosis. suppression of p33 ing1b is associated with the loss of cellular growth control. however, p33 ing1b expression in crc and its correlations with clinicopat...

objective(s) p53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. the aim of this study was to reveal mutations of tp53 in colorectal cancer in kerman province. materials and methods a total of forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage iiia, were selected. three exons 5, 7 ...