نتایج جستجو برای: tumor peptide

تعداد نتایج: 576890  

ژورنال: :مجله دانشگاه علوم پزشکی مازندران 0
عقیل تبارملاحسن a tabar molla hassan نفیسه پاکروان n pakravan محمدحسن زهیر m.h zahir faculty of medicine, tarbiat modarres university of medical sciences, tehran, iranدانشجوی دکترای تخصصی ایمونولوژی دانشگاه تربیت مدرس علی مصطفایی a mostafaie سیدمحمد موذنی s.m moazeni معصومه ابتکار m ebtekar شهرام شهابی

سابقه و هدف: با وجود پیشرفت های زیاد در زمینه درمان تومور با استفاده از روش های رایج مانند جراحی، شیمی درمانی و غیره، علم پزشکی همچنان در درمان تومور ناتوان مانده است. در این رابطه علم ایمونولوژی افق تازه ای را جهت رییشه کنی تومور ارایه نموه به صورتی که ایمونوتراپی تومور امروزه به عنوان یکی از استراتژی های پذیرفته شده در درمان بعضی از انواع تومورها حداقل در مدل های حیوانی نتایج قابل قبولی را ار...

Journal: :iranian journal of pharmaceutical research 0
sheyda shariat department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran ali badiee nanotechnology research center,school of pharmacy, mashhad university of medical sciences, mashhad, iran mahmoud reza jaafari biotechnology research center, nanotechnology research center ,school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran

the purpose of this study was to optimize a method for the encapsulation of p5 peptide, a new designed peptide containing mhc class i epitopes from rat her2/neu protein, into liposomes as an approach for breast cancer vaccine formulation. the efficiency of liposomal encapsulation of peptides is generally low and development of an optimized method to increase encapsulation efficiency is a big ch...

Ali Badiee Mahmoud Reza Jaafari, Mercedeh Mansourian Seyed Alireza Mortazavi, Seyed Amir Jalali, Sheida Shariat

Objective(s):Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for anticancer immunotherapy. However, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone.The aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic HER2/neu derived pept...

Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years. The better biomedical properties of radioantagonists as higher tumor uptake make these radioligands more attractive than agonists for somatostatin receptor-targeted radionuclide therapy. In this study...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

Journal: :iranian journal of basic medical sciences 0
sheida shariat department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran ali badiee nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed amir jalali department of immunology, medical school, shahid beheshti university of medical sciences, tehran, iran mercedeh mansourian nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran seyed alireza mortazavi department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran mahmoud reza jaafari biotechnology research center, nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s):tumor-associated antigen (taa) subunit-based vaccines constitute promising tools for anticancer immunotherapy. however, a major limitation in the development of such vaccines is the poor immunogenicity of peptides when used alone.the aim of this study was to develop an efficient vaccine delivery system and adjuvant to enhance anti-tumor activity of a synthetic her2/neu derived pept...

آزادمهر , عباس, آقاجان زاده , سیدحمید, ابتکار , معصومه, تبارملاحسن , عقیل, زهیر, محمدحسن , شاهین جعفری, آریو, شهابی , شهرام, مصطفایی , علی, موذنی , سیدمحمد, میرابی عراز, محمد, پاکروان , نفیسه,

Background and purpose: In spite of the increasing progress in tumor treatment by current methods like surgery, chemotherapy and etc, medical sciences are unable to treat tumors. In this respect, immunology has opened a new window for tumor treatment nowadays tumor immunotherapy is an accepted strategy for treatment of some tumors at least in some animal models. The goal of this study is the ...

Objective(s): Despite recent advances in treatment modalities, cancer remains a major source of morbidity and mortality throughout the world. Currently, the development of sensitive and specific molecular imaging probes for early diagnosis of cancer is still a problematic challenge. Previous studies have been shown that some of the antimicrobial peptides (AMPs) exhibit...

ژورنال: یافته 2017
اصغری, سید محسن, جعفرزاده, مهرزاد, جغتایی, محمدتقی, موسوی زاده, سید کاظم,

Background: Today, breast cancer is the biggest health threat to women. The current common treatments include surgery, chemotherapy, and radiotherapy. In most cancers, metastasis is the primary cause of treatment failure. Surgery and radiotherapy are effective on local tumors, but they cannot affect metastatic cancers. Chemotherapy is often used to treat metastatic cancers, the effectiveness of...

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with 99mTc via HYNIC chelator and tricine as co-ligand. Also, stability in human serum, receptor bound internalization and tissue biodistribution in tumor bearing nude m...

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