background vitamin d (vit d) level may change variously in serums of patients undergoing anti-tuberculosis (anti-tb) therapy using antibiotics such as isoniazid and rifampin. objectives the current study aimed to evaluate all components of calcium (ca) regulatory agents in the six- month period of standard anti- tb therapy. patients and methods eight adults whose pulmonary tb had been diagnosed...

An increasing incidence of deaths due to tuberculosis and the known drawbacks of the current existing drugs including the emergence of multi drug-resistant strains have led to a renewed interest in the discovery of new anti-tubercular agents with novel modes of actions. The recent researches focused on natural products have shown a useful way to obtain a potentially rich source of drug candidat...

Prior to the availability of effective therapy, tubercular meningitis was invariably fatal with most of the deaths occurring within weeks of initial presentation. Although antimicrobial agents have improved the survival rates, serious sequelae are still common. With the advent of CT scan, hydrocephalus can be diagnosed early and neurosurgical intervention can improve the outcome in such subject...

MmpL3 is a promising target for novel anti-tubercular agents, with numerous compound series identified as MmpL3 inhibitors. Despite this, there is an incomplete understanding of MmpL3 function. Here we show that Mycobacterium smegmatis MmpL3 mutant strains had an altered cell wall hydrophobicity, disrupted membrane potential and growth defects in liquid media. Compensatory mutations that restor...

musculoskeletal tuberculosis accounts for 1-2% of all types of tuberculosis. tubercular abscess of the chest wall accounts for 1-5% of all cases of musculoskeletal tuberculosis. herein, we report a case of tubercular abscess of the chest wall. the occurrence of caries rib and cold abscess of the chest wall with concomitant pulmonary tuberculosis, and tubercular lympha-denitis of neck and medias...