Background: TSPP is a 27 poly-epitope peptide anti-cancer vaccine which includes the amino acidic sequences of 3 known CTL-epitopes with HLA-A(*)02.01 binding motifs, contained in the thymidylate synthase (TS), a tumourassociated enzyme antigen critical for DNA synthesis and repair. The immunological and antitumor activity of TSPP has already been tested in preclinical studies, whose results of...

The interactions of 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrin (TSPP, a singlet oxygen photosensitiser molecule) with a hexa-2,4-diynediyl bridged β-cyclodextrin dimer (CD-CD) in aqueous solutions of pH 7 were studied using steady-state UV-visible absorption/emission and femto- to millisecond time-resolved spectroscopy. TSPP forms 1 : 1 complexes with CD-CD (K(e) = 1.9 × 10(8) M(-1) at 29...

This work reports the synthesis and characterization of the first water-soluble iridium porphyrin, iridium(iii) diaqua porphyrin [Ir(III)(TSPP)(OH(2))(2)](3-) (1, TSPP = tetra-p-sulfonatophenyl porphyrin). The structure of 1 was unequivocally determined by single crystal X-ray analysis. Benzo-18-crown-6-ether is essential for producing single crystals suitable for X-ray analysis.

The manuscript describes the characterization of the interaction between meso-tetrakis(p-sulfonatophenyl)porphyrin (TSPP) and human serum albumin (HSA). TSPP is a candidate for the photosensitization of structural and functional changes in proteins while HSA provides both an excellent protein model and binding and functional characteristics that could be explored in future applications of the a...

Mixed Langmuir monolayers and Langmuir-Schaefer (LS) films containing the cationic metallosurfactant bis(2-phenylpyridine)(4,4'-diheptadecyl-2,2'-bipyridine)-iridium(III) chloride (Ir-complex) and the anionic tetrakis(4-sulfonatophenyl)porphyrin (TSPP) in 4:1 molar ratio have been successfully prepared by the co-spreading method at the air-water interface. The presence of both luminescent speci...

Aim: The experiment was conducted to study the total seminal plasma protein (TSPP) and heparin-binding proteins (HBPs) in relation to initial semen quality of buffalo bull. Materials and Methods: Semen from two Murrah buffalo bulls (bull no. 605 and 790) with mass motility of ≥3+ were used for the study and categorized into three groups (Group IMass motility 3+, Group IIMass motility 4+ and Gro...

The metalloporphyrins, Me-TSPP [Me=Cr(III), Mn(III), Mn(II), Fe(III), and TSPP=meso-(tetra-p-sulfonatophenyl)porphyrin], which possess electron spins S=3/2, 2, 5/2, and 5/2, respectively, comprise an important series of model systems for mechanistic studies of NMR paramagnetic relaxation enhancement (NMR-PRE). For these S>1/2 spin systems, the NMR-PRE depends critically on the detailed form of ...

You, J., X. Zhao, Y. Suo, Y. Li, H. Wang, and G. Chen, Determination of LongChain Fatty Acids in Bryophyte Plant Extracts by HPLC with Fluorescence Detection and Identification with MS, J. Chromatogr. B 848:283–291, 2007. A sensitive method has been developed for the determination of long-chain fatty acids (LCFAs) (>C20) using 1-[2-(ptoluenesulfonate)-ethyl]-2-phenylimidazole-[4,5-f]-9,10-phena...

The binding of TSPP by a dithienylethene-tethered beta-cyclodextrin dimer can be altered reversibly by irradiation with light.

Water-soluble quantum dot-organic dye nanocomposites have been prepared via electrostatic interaction. We used CdTe quantum dots with diameters up to 3.4 nm, 2-aminoethanethiol as a stabilizer, and meso-tetra(4-sulfonatophenyl)porphine dihydrochloride (TSPP) as an organic dye. The photophysical properties of the nanocomposite have been investigated. The fluorescence of the parent CdTe quantum d...