background l-tryptophan is an important ingredient in medicines, especially in neuromedicines such as antidepressants. many commercial processes employ various microorganisms with high tryptophan synthase activity to produce l-tryptophan from indole and l-serine, but these processes are very costly due to the costs of precursors, especially l-serine. objectives for this reason, we studied the a...

background: l-tryptophan is used widespread in the pharmaceutical industry. the majority of l-trp production depends on microbial processes that produce l-tryptophan from indole and l-serine. these processes are very costly due to the costs of precursors, especially l-serine. use of inexpensive substitutions as the l-serine source of l-tryptophan production enables us to reach a cost-effective ...

abstract now, it’s completely proved that we can find strains among many strains of each rhizobial group that can also do effective process in plant growth promoting as plant growth hormones production (iaa), in addition of their ability in n2 fixation .therefore, the aim of this research is to determinate the ability of iaa production of some of the indigenous rhizobial strains by two quantita...

surfactant molecules are used as interesting tools to study the structure, function and stability of proteins. protonation states of amino acids may be changed in the presence of surfactants. in this work, using experimental observations and molecular dynamic simulation, the effects of sodium dodecyl sulfate on the acid dissociation constants of tryptophan was examined. the acid–base equilibriu...

bacteria of the genus azospirillum are well known as plant growth promoting rhizobacteria. the ability to synthesize phytohormones is considered one of the most important mechanisms to promote plant growth and is widely distributed among plant-associated rhizobacteria.the most important phytohormone produced by azospirillum is the auxin indole-3-acetic acid, with the l-tryptophan as the precurs...

indoleamine 2,3-dioxygenase (ido), an enzyme involved in the catabolism of tryptophan, is expressed by a variety of cells and tissues such as macrophages, dendritic cells, cells of the endocrine system and by the placenta. ifn- γ is the main inducer of this enzyme. ido acts as an important defense mechanism of innate immunity against pathogens. it also has tumor suppressive activity and prolong...

To obtain a better understanding of the mycorrhizas as an elicitor, and precursor feeding effects on the protein content and TIAs biosynthesis in Catharanthus roseus L., foliar application of four concentrations of tryptophan (0, 150, 250 and 350 mg/l) on some growth parameters and chemical compositions of mycorrhizal plants were investigated. The results revealed that the total protein content...

background and objectives: the essential amino acid l-tryptophan can be produced by a condensation reaction between indole and l-serine, catalyzed by b. subtilis with tryptophan synthase activity. application of the tryptophan is widespread in the biotechnology domain and is sometimes added to feed products as a food fortifier. materials and methods: the optimum concentration of the iranian can...

Objective: Interferon-α (IFN) therapy can cause depressive symptom which may lead to drug discontinuation. By interfering with tryptophan pathway, the available level of tryptophan required for serotonin synthesis decreases which could be related to depression. The aim of this study was to evaluate whether soybean diet could improve IFN-induced depression. Materials and Methods: Male mice weigh...