نتایج جستجو برای: trpv cation channels

تعداد نتایج: 190600  

Journal: :iranian journal of basic medical sciences 0
elham hakimizadeh physiology-pharmacology research centre, rafsanjan university of medical sciences, rafsanjan, iran department of biology, science and research branch, islamic azad university, tehran, iran shahrbanoo oryan department of biology, science and research branch, islamic azad university, tehran, iran akbar hajizadeh moghaddam department of biology, faculty of basic sciences, university of mazandaran, babolsar, iran ali shamsizadeh physiology-pharmacology research centre, rafsanjan university of medical sciences, rafsanjan, iran ali roohbakhsh physiology-pharmacology research centre, rafsanjan university of medical sciences, rafsanjan, iran

objective(s) fatty acid is amide hydrolase which reduce endogenous anandamide. transient receptor potential vanilloid-1 (trpv1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. in the present study, the effects of either endocannabinoid system or trpv1 channels and their possible interaction on anxiety-like behaviors of the rats were explored. m...

2003
Rosa Planells-Cases Carolina García-Martínez Miriam Royo Enrique Pérez-Payá Cristina Carreño Fernando Albericio Angel Messeguer Antonio Ferrer Miguel Hernández

Journal: :Current pharmaceutical design 2008
Rudi Vennekens Grzegorz Owsianik Bernd Nilius

The mammalian branch of the Transient Receptor Potential (TRP) superfamily of cation channels consists of 28 members. They can be subdivided in six main subfamilies: the TRPC ('Canonical'), TRPV ('Vanilloid'), TRPM ('Melastatin'), TRPP ('Polycystin'), TRPML ('Mucolipin') and the TRPA ('Ankyrin') group. The TRPV subfamily comprises channels that are critically involved in nociception and thermo-...

Journal: :Molecular pharmacology 2005
Gang Lu Dorian Henderson Lieju Liu Peter H Reinhart Sidney A Simon

Transient receptor potential (TRP) genes encode a family of related ion-channel subunits. This family consists of cation-selective, calcium-permeable channels that include a group of vanilloid receptor channels (TRPV) implicated in pain and inflammation. These channels are activated by diverse stimuli, including capsaicin, lipids, membrane deformation, heat, and protons. Six members of the TRPV...

Journal: :Neuron 2000
David B Reichling Jon D Levine

ceptors, and following the cloning of VR1 the search for If the fire is near the foot, the particles of this fire... have other vanilloid receptor family members began. To date, the power to move the area of the skin of this foot that three related molecules have been identified. The vanilthey touch... at the same instant they open the entrance loid receptor–like protein subtype 1 (VRL-1) does ...

2007
Pierluigi Valente Nuria García-Sanz Ana Gomis Asia Fernández-Carvajal Gregorio Fernández-Ballester Felix Viana Carlos Belmonte Antonio Ferrer

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante, Spain; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Alicante, Spain. These authors contributed equally to this work. Running head: TRP box involvement in TRPV1 gating Address correspondence to: Antonio Ferrer-Montiel, PhD, Instituto de Biología Molecular y Celular, Universidad Miguel...

Journal: :Bioorganic & medicinal chemistry letters 2003
JungWha Yoon HyeYoung Choi Hyun Joo Lee Chong Hyun Ryu Hyeung-geun Park Young-ger Suh Uhtaek Oh Yeon Su Jeong Jin Kyu Choi Young-Ho Park Hee-Doo Kim

A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 microM of IC(50) value in 45Ca(2+)-influx assay.

Journal: :Journal of Biomedical and Pharmaceutical Research 2021

Journal: :American journal of physiology. Lung cellular and molecular physiology 2006
Xiao-Ru Yang Mo-Jun Lin Lionel S McIntosh James S K Sham

Transient receptor potential melastatin- (TRPM) and vanilloid-related (TRPV) channels are nonselective cation channels pertinent to diverse physiological functions. Multiple TRPM and TRPV channel subtypes have been identified and cloned in different tissues. However, their information in vascular tissue is scant. In this study, we sought to identify TRPM and TRPV channel subtypes expressed in r...

Journal: :Molecular pharmacology 2009
Joris Vriens Giovanni Appendino Bernd Nilius

Depending on their primary structure, the 28 mammalian transient receptor potential (TRP) cation channels identified so far can be sorted into 6 subfamilies: TRPC ("Canonical"), TRPV ("Vanilloid"), TRPM ("Melastatin"), TRPP ("Polycystin"), TRPML ("Mucolipin"), and TRPA ("Ankyrin"). The TRPV subfamily (vanilloid receptors) comprises channels critically involved in nociception and thermosensing (...

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