نتایج جستجو برای: trophoblast

تعداد نتایج: 4993  

Journal: :Reproductive Biomedicine Online 2021

Research questionWhich are the early compartment-specific transcriptional responses of trophoblast and endometrial epithelium throughout attachment during implantation?DesignAn proxy (cell line Ishikawa) was co-cultured with spheroids a green fluorescent protein (GFP) expressing cell (JEG-3). After 0, 8 24 h co-culture, compartments were sorted by fluorescence-activated sorting; GFP+ (trophobla...

Journal: :Differentiation; research in biological diversity 2005
Namita Sahgal Lindsey N Canham Toshihiro Konno Michael W Wolfe Michael J Soares

Trophoblast giant cells are located at the maternal-embryonic interface and have fundamental roles in the invasive and endocrine phenotypes of the rodent placenta. In this report, we describe the experimental modulation of trophoblast stem cell and trophoblast giant cell phenotypes using the Rcho-1 trophoblast cell model. Rcho-1 trophoblast cells can be manipulated to proliferate or differentia...

Journal: :Endocrinology 1995
G P Hamlin M J Soares

This report investigates the regulation of DNA synthesis in trophoblast stem cells and differentiating trophoblast cells. Experiments in this study were performed on the Rcho-1 trophoblast cell line, which was established from a transplantable rat choriocarcinoma. Rcho-1 trophoblast cells can be manipulated to proliferate or differentiate along the trophoblast giant cell pathway. DNA synthesis ...

Journal: :Developmental biology 2003
Rupasri Ain Lindsey N Canham Michael J Soares

Trophoblast cell invasion into the uterine wall is characteristic of hemochorial placentation. In this report, we examine trophoblast cell invasion in the rat and mouse, the endocrine phenotype of invasive trophoblast cells, and aspects of the regulation of trophoblast cell invasion. In the rat, trophoblast cells exhibit extensive interstitial and endovascular invasion. Trophoblast cells penetr...

Journal: :Biology of reproduction 2003
Peter Kaufmann Simon Black Berthold Huppertz

Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries are invaded by endovascular trophoblast and remodeled into dilated, inelastic tubes without maternal vasomotor control. Disturbed remodeling is associated with maintenance of high uteroplacental vascular resistance and ...

Journal: :Endocrinology 1999
K E Orwig M J Soares

The decidual/trophoblast PRL-related protein (d/tPRP) is dually expressed by decidual and trophoblast cells during pregnancy. We have characterized the proximal d/tPRP promoter responsible for directing d/tPRP expression in decidual and trophoblast cells. We have demonstrated that the proximal 93 bp of d/tPRP 5'-flanking DNA are sufficient to direct luciferase gene expression in primary decidua...

Journal: :Molecular and cellular biology 2010
Peter Kuckenberg Sandra Buhl Tatiana Woynecki Betina van Fürden Elena Tolkunova Friederike Seiffe Markus Moser Alexey Tomilin Elke Winterhager Hubert Schorle

In mammals, cell lineage specification is established at the blastocyst stage. At this stage, transcription factor Cdx2 represses pluripotency genes, thus promoting extraembryonic trophoblast fate. Recently, transcription factor Gata3 was shown to act in a parallel pathway in promoting trophoblast cell fate, suggesting that there are more factors working in the trophoblast lineage. Here, we rep...

2016
Miguel R. Branco Michelle King Vicente Perez-Garcia Aaron B. Bogutz Matthew Caley Elena Fineberg Louis Lefebvre Simon J. Cook Wendy Dean Myriam Hemberger Wolf Reik

Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA methylation in trophoblast development by performing mRNA and DNA methylation profiling of Dnmt3a/3b mutants. We find that oocyte-derived methylation plays a ma...

Journal: :The Journal of Cell Biology 1978
D. M. Nelson A. C. Enders B. F. King

Electron microscope autoradiography has been used to study protein synthesis in syncytial and cellular trophoblast of term human placental villi incubated in vitro with tritiated leucine ([3H]leu). Autoradiographs were analyzed using the hypothetical grain analysis of Blackett and Parry (1973. J. Cell Biol. 57:9-15). The results of this study demonstrated that both cellular and syncytial tropho...

2014
Víctor A. Francis Aron B. Abera Mushi Matjila Robert P. Millar Arieh A. Katz

The precise regulation of extravillous trophoblast invasion of the uterine wall is a key process in successful pregnancies. Kisspeptin (KP) has been shown to inhibit cancer cell metastasis and placental trophoblast cell migration. In this study primary cultures of first trimester human trophoblast cells have been utilized in order to study the regulation of invasion and angiogenesis-related gen...

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