the ethyl acetate partition of dried methanolic extract of aerial parts of euphorbia microsciadia (euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. these three compounds were structurally compared through their mass ...

dried aceton-chloroform extract of aerial parts of euphorbia spinidens bornm. ex prokh. endemic to iran, yielded two new triterpenoids, lup-20(29)-ene-33, 28 diol commonly known as betulin and (3β,23e)-cycloarta-23-ene-3,25-diol. the structures of the isolated compounds were elucidated by 13 c- and 1 h-nmr as well as 2d-nmr, ir and by the aid of mass fragmentation pattern. in phagocyte chemilum...

A comprehensive investigation was carried out to minimize the cost price of the rock fragmentation process including: drilling, blasting, secondary blasting and separating the large boulders (oversize rocks) while loading, until the optimized fragmentation, powder factor and ratio of burden (B) to blasthole diameter (?h) were achieved by doing several stages of drilling and blasting practically...

The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...

The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...

Acyl-coenzyme A (CoA):cholesterol acyltransferase (ACAT) catalyzes the intracellular fatty acid esterification of cholesterol and is thought to play a key role in lipoprotein metabolism and atherogenesis. Herein we describe the purification and characterization of a novel pentacyclic triterpene ester from rabbit liver that has ACAT inhibitory activity. The inhibitor was purified by a combinatio...

Geoditin A, an isomalabaricane triterpene isolated from the marine sponge Geodia japonica, has been demonstrated to dissipate mitochondrial membrane potential, activate caspase 3, decrease cytoplasmic proliferating cell nuclear antigen (PCNA), and induce apoptosis of leukemia cells, but the underlying mechanism remains unclear [1]. In this study, we found fragmentation of Golgi structure, suppr...

Mass spectrometry allows sensitive, automated, and high-throughput analysis of small molecules. In principle, tandem mass spectrometry allows us to identify "unknown" small molecules not in any database, but the automated interpretation of such data is in its infancy. Fragmentation trees have recently been introduced for the automated analysis of the fragmentation patterns of small molecules. W...

Mass spectrometry is one of the key technologies in metabolomics for the identification and quantification of molecules in small concentrations. For identification, these molecules are fragmented by, e.g., tandem mass spectrometry, and masses and abundances of the resulting fragments are measured. Recently, methods for de novo interpretation of tandem mass spectra and the automated inference of...

Dried aceton-chloroform extract of aerial parts of Euphorbia spinidens Bornm. ex Prokh. endemic to Iran, yielded two new triterpenoids, lup-20(29)-ene-33, 28 diol commonly known as betulin and (3β,23E)-Cycloarta-23-ene-3,25-diol. The structures of the isolated compounds were elucidated by 13C- and 1H-NMR as well as 2D-NMR, IR and by the aid of mass fragmentation pattern. In phagocyte chemilumin...