BACKGROUND Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown. OBJECTIVE To determine the influence of receptor tyrosine kinases, which are both expressed in pulmonary carcinomas and in human skin, we performed expression studies on epidermal growth...

AN: acanthosis nigricans CTD: connective tissue disease ILD: interstitial lung disease NSIP: nonspecific interstitial pneumonia TP: tripe palms INTRODUCTION Tripe palms [(TP); acral acanthosis nigricans (AN)], is a rare cutaneous syndrome in which the palms develop velvety thickening and rugosity that creates an exaggeration or distortion of dermatoglyphics, resembling boiled tripe. In more tha...

Malignant acanthosis nigricans is a rare paraneoplastic skin syndrome mostly associated with gastric adenocarcinoma. Florid cutaneous papillomatosis and tripe palms syndrome are considered to be abortive clinical variants of acanthosis nigricans. Clinical manifestations include pruritic, hyperkeratotic and hyperpigmented plaques with a subsequent formation of velvety papillomas in the involved ...

Tripe palms, which described the thickening of pamar skin with increase of normal dermatoglyphics and a peculiar velvety texture, is a specific cutaneous paraneoplastic syndrome especially related to cancers of upper aerodigestive tract. Acanthosis nigricans, and florid cutaneous papillomatosis (sudden appearance of many warty skin lesions) are the most commonly associated paraneoplastic dermat...

Malignant acanthosis nigricans is a cutaneous eruption characterized by symmetric hyperpigmented hyperkeratosis, dermal papillomatosis, and mucosal involvement associated with internal malignancies. Tripe palms refers to a characteristic velvety thickening of the palms, with exaggeration of normal skin markings. We present the second case of ovarian cancer in association with two coexisting par...

This paper reports the case of a 57-year-old, previously healthy male with no systemic symptoms who over a short period of time developed multiple wart-like lesions on his trunk, limbs and face, typical lesions of acanthosis nigricans in the major body folds and tripe palms. Diagnostic tests revealed a metastatic gastric adenocarcinoma. Despite the implementation of therapy, which had a transie...

A 38-year-old female presented with hyperpigmented velvety plaques on the nape and the sides of the neck with diffuse pigmentation of the face and flexures suggestive of acanthosis nigricans. The dorsa of both the hands showed increased rugosity, hyperpigmentation and hyperkeratosis of the palms, suggestive of tripe palms. Investigations revealed multiple secondaries in the liver. Histopatholog...

acanthosis nigricans (an), tripe palm (tp) and sign of lesser trelat (lt) are rare dermatoses which are often seen with malignant conditions. acanthosis nigricans occurs both on the skin and mucus membranes as velvety hyper pigmented lesions in the flexors and around the neck, or papillomatous and verrucous lesions on the lips and buccal mucosa. these para neoplastic dermatoses are generally li...