Inner ear hair cells detect sound through deflection of mechanosensory stereocilia. Each stereocilium is supported by a paracrystalline array of parallel actin filaments that are packed more densely at the base, forming a rootlet extending into the cell body. The function of rootlets and the molecules responsible for their formation are unknown. We found that TRIOBP, a cytoskeleton-associated p...

TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F‑actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87‑MG and U343‑MG cells. Furthermore, the TrioBP mRNA expression level ...

We have previously proposed that specific proteins may form insoluble aggregates as a response to an illness-specific proteostatic dysbalance in a subset of brains from individuals with mental illness, as is the case for other chronic brain conditions. So far, established risk factors DISC1 and dysbindin were seen to specifically aggregate in a subset of such patients, as was a novel schizophre...

Hearing loss (HL) is the most common sensory defect. Various genetic as well as environmental factors have been shown to contribute in it. More than 100 loci have been recognized to cause autosomal recessive nonsyndromic hearing loss (ARNSHL). Here, we report a 6-year old female patient with bilateral pre-lingual HL in whom a mutation has been identified in TRIOBP gene (c.6362C>T, S2121L). In s...

The University has 3 active pension plans. Faculty, Excluded Faculty, Professional/Managerial staff, College Academic/Research Group and Ontario Nurses Association employees participate in the Professional Pension Plan [2]. UGFSEA Units 1 & 2 and OSSTF/TARA District 35 members enrolled on or after October 1, 2014 participate in the Non-Professional Pension Plan [3]. All other eligible employees...

Background: Disrupted proteostasis is an emerging area of research into major depressive disorder. Several proteins have been implicated as forming aggregates specifically in the brains subsets patients with psychiatric illnesses. These include CRMP1, DISC1, NPAS3 and TRIOBP-1. It unclear, however, whether these normally aggregate together same individuals and, if so, each protein independently...

The University has 3 active pension plans. Faculty, Excluded Faculty, Professional/Managerial staff, College Academic/Research Group and Ontario Nurses Association employees participate in the Professional Pension Plan [2]. UGFSEA Units 1 & 2 and OSSTF/TARA District 35 members enrolled on or after October 1, 2014 participate in the Non-Professional Pension Plan [3]. All other eligible employees...

The University has 3 active pension plans. Faculty, Excluded Faculty, Professional/Managerial staff, College Academic/Research Group and Ontario Nurses Association employees participate in the Professional Pension Plan [2]. UGFSEA Units 1 & 2 and OSSTF/TARA District 35 members enrolled on or after October 1, 2014 participate in the Non-Professional Pension Plan [3]. All other eligible employees...

The University has 3 active pension plans. Faculty, Excluded Faculty, Professional/Managerial staff, College Academic/Research Group and Ontario Nurses Association employees participate in the Professional Pension Plan [2]. UGFSEA Units 1 & 2 and OSSTF/TARA District 35 members enrolled on or after October 1, 2014 participate in the Non-Professional Pension Plan [3]. All other eligible employees...

The University has 3 active pension plans. Faculty, Excluded Faculty, Professional/Managerial staff, College Academic/Research Group and Ontario Nurses Association employees participate in the Professional Pension Plan [2]. UGFSEA Units 1 & 2 and OSSTF/TARA District 35 members enrolled on or after October 1, 2014 participate in the Non-Professional Pension Plan [3]. All other eligible employees...