coenzyme q10 is a promising   agent for neuroprotection in neurodegenerative   diseases. neuroprotective effects of coenzyme q10 demonstrated in some   neurodegenerative diseases such as parkinson, alzheimer and etc. hippocampus   is home of these diseases. we assayed coenzyme q10 effects on hippocampal   injury model and our hypothesis is that coenzyme q10 has neuroprotective   effects in some...

In the present study, patch-clamp techniques have been used to investigate the effect of trimethyltin chloride (Met3SnCl) on the slow vacuolar (SV) channels in vacuoles from red beet (Beta vulgaris L.) taproots. Activity of SV channels has been measured in whole-vacuole and cytosolic side-out patch configurations. It was found that addition of trimethyltin chloride to the bath solution suppress...

Alkyl compounds of tin chlorides are widely used for the production of plastics in the chemical industry. They inhibit the dissociation of hydrochloric acid from polyvinyl chloride (PVC) and in combination with PVC they are not toxic. However, as free molecules, organic tin compounds are highly toxic in contrast to inorganic tin compounds. The toxic components are dimethyltin chloride and trime...

conclusions the results of the present study indicate that coenzyme q10 diminished neuronal necrosis and improved learning memory. part of its beneficial effect is due to its potential to discount oxidative stress. results this study revealed that the body weight scale was found to be significantly higher in the coq10 group (21.39 ± 2.70), compared to the tmt group (19.39 ± 2.74) (p < 0.05). in...

In exploratory studies aimed at elucidating CNS effects due to heavy metal toxicity, signs of compromised renal function were seen in rats. The studies reported here describe the sequential steps of the development of nephrotoxicity by trimethyltin chloride (TMT) in rats. Single doses of 12.25 mg/kg TMT administered orally to 150- to 175-g Long-Evans rats elicited overt signs of toxicity includ...

The in vivo effect of trimethyltin chloride (Me3SnCl), free base meso-tetrakis(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin (R 4PH2) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals ...

Physiological modifications of intracellular Ca2+ ([Ca2+]i) levels trigger and/or regulate a diversity of cellular activities (e.g. neurotransmitter release, synaptic plasticity, muscular contraction, cell proliferation), while calcium overloads could result in cytotoxicity. Previously, we have shown that trimethyltin chloride (Me3SnCl; TMT) modulates calcium homeostasis in cervix adenocarcinom...

Humans are exposed to organotins, like trimethyltin (TMT) chloride via air, water and food, and intoxication might result in severe health complications. Toxic effects of organotin compounds are well documented, but possible mechanisms remain unclear and only little information is available how organometallic species interact with calcium controlling mechanisms. Therefore, the aim of this work ...