background: tricyclic antidepressants (tcas) poisoning is the most common poisoning in the poisoning emergency department of noor hospital, isfahan, iran. the objective of this study was to compare qrs interval duration with ravr³3mm and r/savr³ 0.7 in predicting: serious complications of acute tca toxicity. methods and materials: this study was descriptive – analytic and prospective cohort. tc...

OBJECTIVE A comprehensive meta-analysis of clinical trial data was performed to assess the possible association of fluoxetine and suicidality (suicidal acts and ideation). DESIGN Retrospective analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder comparing fluoxetine (n = 1765) with a tricyclic antidepressant (n = 731) or placebo (n = 569), or...

background: migraine is a chronic  neurological  disorder, characterized  by recurrent  moderate to severe headaches. worldwide migraine a=ects nearly 15%. studies suggest that genes involved in the production of nitric oxide (no) may act as genetic  factors for migraine. no synthase  3 (nos3) by expressing  enzyme nos regulates  endothelial  derived no. one  class of  medications   used  as  f...

SSRIs are chemically distinct from traditional antidepressants such as tricyclic, tetracyclic, and monoamine oxidase inhibitors, but they share the same mechanism of action in that selectively potently inhibit serotonin neuronal reuptake while having no or very little effect on norepinephrine, acetylcholine, histamine reuptake. As a result, when compared to other tricyclic tetracyclic antidepre...

Children and adolescents suffering from anxiety disorders may require pharmacotherapy. Tricyclic antidepressants are often prescribed in these instances. Unfortunately, most clinical research analyzing the effectiveness of tricyclic antidepressants on anxiety disorders has focused exclusively on adult patients. This critical review examines those studies that have investigated the effects of tr...

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...