background major depressive disorder (mdd) is the most common disorder in our community. hypericum perforatumm, is a herb with a long application history in treating depression. a controlled study to evaluate the effects of this herbal medicine in iran did not exist. objectives this study aimed to assess the effect of hypericum perforatom (perforan), in combination with tricyclic antidepressant...

A concise and stereoselective total synthesis of the clinically relevant tricyclic prostaglandin D2 metabolite (tricyclic-PGDM) methyl ester in racemic form was accomplished eight steps from a readily available known cyclopentene-diol derivative. The features nickel-catalyzed Ueno–Stork-type dicarbofunctionalization to generate two consecutive stereocenters, palladium-catalyzed carbonylative sp...

The authors report four cases of Monopolar Depressed patients who developed manic features for the first time while on tricyclic antidepressant therapy. The phenomenon is viewed as tricyclic antidepressant induced mania. The manic symptoms occurred late in therapy, with moderate doses of tricyclic antidepressants (125-150 mg per day) and were easily controlled with antipsychotic medication. Fac...

OBJECTIVE A comprehensive meta-analysis of clinical trial data was performed to assess the possible association of fluoxetine and suicidality (suicidal acts and ideation). DESIGN Retrospective analysis of pooled data from 17 double blind clinical trials in patients with major depressive disorder comparing fluoxetine (n = 1765) with a tricyclic antidepressant (n = 731) or placebo (n = 569), or...

Gas chromatography±mass spectrometry (GC±MS) and GC±MS±MS analyses of heavy oils from Bolivar Coastal Fields (Lagunillas Field) show a complete set of demethylated tricyclic terpanes. As is the case for the 25-norhopanes, the demethylated tricyclics are probably formed in reservoirs by microbially-mediated removal of the methyl group from the C-10 position, generating putative 17-nor-tricyclic ...

SSRIs are chemically distinct from traditional antidepressants such as tricyclic, tetracyclic, and monoamine oxidase inhibitors, but they share the same mechanism of action in that selectively potently inhibit serotonin neuronal reuptake while having no or very little effect on norepinephrine, acetylcholine, histamine reuptake. As a result, when compared to other tricyclic tetracyclic antidepre...

Cross hepatotoxicity between drugs in very uncommon. We report the case of a patient in whom acute hepatitis was induced by a tricyclic antidepressant, amineptine, and recurred early after administration of another tricyclic antidepressant, clomipramine. This observation suggests that the tricyclic ring is involved in the mechanism of the deleterious effect of both drugs to the liver.

In this paper, some new properties are presented to the extremal graphs with largest (signless Laplacian) spectral radii in the set of all the connected graphs with prescribed degree sequences, via which we determine all the extremal tricyclic graphs in the class of connected tricyclic graphs with prescribed degree sequences, and we also prove some majorization theorems of tricyclic graphs with...