objective(s):higher cellular reactive oxygen species (ros) levels is important in reducing cellular energy charge (ec) by increasing the levels of key metabolic protein, and nitrosative modifications, and have been shown to damage the cardiac tissue of diabetic mice. however, the relation between energy production and heart function is unclear. materials and methods:streptozotocin (stz, 150 mg/...

Bacillus thuringiensis sporulates in a glucose-glutamate medium without concurrent derepression of the tricarboxylic acid cycle. Glutamate appears to regulate tricarboxylic acid cycle activity as well as to influence spore heat resistance and production of dipicolinic acid.

The enzymes of the Krebs tricarboxylic acid cycle in mitochondria are proposed to form a supramolecular complex, in which there is channeling of intermediates between enzyme active sites. While interactions have been demonstrated in vitro between most of the sequential tricarboxylic acid cycle enzymes, no direct evidence has been obtained in vivo for such interactions. We have isolated, in the ...

The presence of a tricarboxylic acid cycle in Penicillium chry8ogenum, as yet, has not been demonstrated conclusively. Ajl (1951) stated that of the mechanisms proposed for oxidation of the 2 carbon fragment in mold metabolism, the evidence for a tricarboxylic acid cycle is the least convincing. This paper presents a study of some of the enzymes of the tricarboxylic acid cycle in cell-free prep...

Acetobacter suboxydans does not contain an active tricarboxylic acid cycle, yet two pathways have been suggested for glutamate synthesis from acetate catalyzed by cell extracts: a partial tricarboxylic acid cycle following an initial condensation of oxalacetate and acetyl coenzyme A. and the citramalate-mesaconate pathway following an initial condensation of pyruvate and acetyl coenzyme A. To d...