purpose: to evaluate the effects of posterior subtenon triamcinolone acetonide (ta) injection on clinical, angiographic, and optical coherence tomographic (oct) features in refractory diabetic macular edema (dme). method: in a randomized double-masked placebo-controlled clinical trial, 38 consecutive patients (64 eyes) with dme refractory to previous laser therapy or not suitable for such treat...

INTRODUCTION Since 1949, when Hench and Kendall introduced the use of cortisone and hydrocortisone, a voluminous literature has accumulated concerning the employment of these agents in allergic diseases. Steroid therapy requires careful thought in view of the evidence that long term treatment can react adversely on the pituitaryadrenal axis. Nevertheless, an injectable steroid may be used in th...

the purpose of this study was to compare the efficacy of retinoic acid 0.05% with triamcinolone acetonide 0.1%, both in an oral base, in the treatment of atrophic and erosive oral lichen planus. thirty patients with clinically proven oral lichen planus were asked to participate in the study. the severity of lesions was scored from 0 (no lesion) to 5 (large erosion), and symptoms were scored ran...

BACKGROUND Subacromial impingement is a common cause of shoulder complaints in general practice. When the initial treatment with acetaminophen and low dose Non Steroidal Anti Inflammatory Drugs fails, triamcinolone acetonide injections are commonly used. Triamcinolone acetonide injections are effective at four to six weeks. Little is known about the pain relief effect of triamcinolone acetonide...

[(3)H]Triamcinolone acetonide (15nm) was incubated with cytosol (150000g fraction) prepared from oviducts of egg-laying hens. The extent of steroid binding, as determined by charcoal assays, was greatest between 2-4h at 4 degrees C. A similar time curve was obtained when cytosol preparations were first fractionated with (NH(4))(2)SO(4) before labelling. The addition of 10mm-Na(2)MoO(4) or 10mm-...

Purpose: To evaluate the influence of triamcinolone acetonide on the proliferation of retinal pigment epithelum cells in an experimental cell culture study. Methods: Pooled fresh porcine retinal pigment epithelium cell cultures were exposed to triamcinolone acetonide in increasing concentrations after the solvent agent had been removed. The proliferation rate was measured using the (3-(4,5-dime...

PURPOSE To study the toxicity of triamcinolone acetonide (Kenalog; Bristol-Meyers Squibb, Princeton, NJ) on retinal pigment epithelial (ARPE-19) and retinal neurosensory (R28) cells. METHODS ARPE-19 and R28 were grown in tissue culture in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum. Cells were treated with 50, 100, and 200 microg/mL concentration of triamcinolo...

Aim: To assess the effect of crystalline triamcinolone acetonide on retinal endothelial cell proliferation in vivo and in vitro. Methods: For in vitro analysis, a sprouting assay was employed. Bovine retinal endothelial cells were stimulated with basic fibroblast growth factor (bFGF) and incubated with different concentrations of triamcinolone acetonide (0.05 mg/ml to 8 mg/ml). For in vivo anal...

AIM To evaluate the effect of different doses of intravitreal triamcinolone acetonide on diffuse diabetic macular oedema. METHODS The prospective, randomised, double masked, clinical interventional study included 27 eyes (27 patients) with diffuse diabetic macular oedema. They were randomly divided into three study groups receiving an intravitreal injection of filtered triamcinolone acetonide...

BACKGROUND Intra-articular corticosteroids are a mainstay in the treatment of knee osteoarthritis, and in clinical trials, they demonstrate a large initial analgesic effect that wanes over one to four weeks with the rapid efflux of drug from the joint. The present study was undertaken to determine if FX006, an extended-release formulation of triamcinolone acetonide, can provide pain relief that...