hub location-allocation problems are currently a subject of keen interest in the research community. however, when this issue is considered in practice, significant difficulties such as traffic, commodity transportation and telecommunication tend to be overlooked. in this paper, a novel robust mathematical model for a p-hub covering problem, which tackles the intrinsic uncertainty of some param...

background: free radical formation and oxidative stress might play an important role in the pathogenesis of parkinson's disease (pd). in vitro data indicate that neuromelanin (nm) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (vmat2). we designed this study to investigate the neuroprotective eff...

Background: Free radical formation and oxidative stress might play an important role in the pathogenesis of Parkinson's disease (PD). In vitro data indicate that neuromelanin (NM) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (VMAT2). We designed this study to investigate the neuroprotective effects ...

Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...

Various psychostimulants targeting monoamine neurotransmitter transporters (MATs) have been shown to rescue cognition in patients with neurological disorders and improve cognitive abilities in healthy subjects at low doses. Here, we examined the effects upon cognition of a chemically synthesized novel MAT inhibiting compound 2-(benzhydrylsulfinylmethyl)-4-methylthiazole (named as CE-104). The e...

centralizing and using proper transportation facilities cut down costs and traffic. hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. a distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

Abstract In traditional parcel delivery operations, customers determine locations and, hence, the performance of a transporter. We exploit this idea and show that can improve efficiency transporter by giving latter flexibility in choosing locations. Two possible policies to enable are presented evaluated. The first policy, conceptually similar roaming vehicle routing, is related presence altern...

During a recent user conference, NI Week 2006, we got a glimpse into the future of the design of Cyber-physical systems. A team of engineering students from Rensselaer Polytechnic Institute (RPI) described their senior design project in a Mechatronics course [1]. For their semester-long project they chose to build a human transport vehicle, inspired by the popular Segway scooter from DEKA Resea...

Centralizing and using proper transportation facilities cut down costs and traffic. Hub facilities concentrate on flows to cause economic advantage of scale and multimodal transportation helps use the advantage of another transporter. A distinctive feature of this paper is proposing a new mathematical formulation for a three-stage p-hub location routing problem with simultaneous pick-ups and de...

Pulmonary hypertension (PH) results from constriction and remodeling of pulmonary vessels. Serotonin contributes to both phenomena through different signaling pathways. The mitogenic effect of serotonin on pulmonary vascular smooth muscle cells is mediated by the serotonin transporter (5-hydroxytryptamine transporter [5-HTT]), whereas its constricting effect is mediated by 5-HT1B/1D and 5-HT2A ...