Clinical experience with transmyocardial laser revascularization has increased significantly over the last few years. Since several transmyocardial laser revascularization studies reported an apparent effect on the relief of angina and the FDA approved reimbursement of transmyocardial laser revascularization procedures in the USA, thousands of patients have been treated worldwide with different...

patients with syndrome x coronary disease represent a heterogeneous group of patients. medical treatment with dilators and calcium channel blockers are not very effective. we evaluated the use of transmyocardial laser revascularization (tmlr) in treating 5 patients with this syndrome. between may 2002 to december 2005, 5 patients with cardiac syndrome x (mean age of 49.7 years) underwent tmlr. ...

Some patients with severe angina have coronary artery disease which is unsuitable for conventional forms of revascularization — coronary angioplasty/ stenting or coronary artery bypass surgery. These patients have usually undergone previous revascularization procedures and have disease which is diffuse and affects the distal part of the coronary circulation. Transmyocardial laser revascularizat...

AIMS Transmyocardial laser revascularization is a treatment for patients with severe angina pectoris not eligible for conventional revascularization. The effects on myocardial function and reversible ischaemia have not been clarified. METHODS AND RESULTS One hundred patients with refractory angina not eligible for conventional revascularization were randomized 1:1 to receive continued optimal...

OBJECTIVES The purpose of this study was to investigate whether a novel fibroblast growth factor-2 gene formulation, providing a localized and sustained availability of the adenoviral vector from a collagen-based matrix, in combination with CO 2 transmyocardial laser revascularization would lead to an enhanced angiogenic response and improved myocardial function. METHODS Fibroblast growth fac...

BACKGROUND Patients with chronic severe angina refractory to medical therapy who cannot be completely revascularized with either percutaneous catheter intervention or coronary artery bypass graft surgery present clinical challenges. Transmyocardial laser revascularization, either as sole therapy or as an adjunct to coronary artery bypass graft surgery, may be appropriate for some of these patie...

OBJECTIVES The purpose of the study was to evaluate clinical effects, exercise performance and effect on maximal oxygen consumption (MVO2) of transmyocardial revascularization with CO2-laser (TMR) in patients with refractory angina pectoris. BACKGROUND Transmyocardial laser revascularization is a new method to treat patients with refractory angina pectoris not eligible for conventional revasc...

AIMS This report aimed to provide an analysis of the data submitted from Europe and Asia on transmyocardial laser revascularization. METHODS AND RESULTS Prospective data was recorded on 967 patients with intractable angina not amenable to conventional revascularization in 21 European and Asian centres performing transmyocardial laser revascularization using the PLC Medical Systems CO2 laser. ...