Intraosseous movement of an unerupted tooth across the midline of the jaw is known as dental transmigration. This infrequent event is mostly found in the mandibular canines. There are four new cases of mandibular canine transmigration presented here. The literature on this anomalous phenomenon is also reviewed.

intraosseous movement of an unerupted tooth across the midline of the jaw is known as dental transmigration. this infrequent event is mostly found in the mandibular canines. there are four new cases of mandibular canine transmigration presented here. the literature on this anomalous phenomenon is also reviewed.

Transmigration of mandibular canines is a rare phenomenom. Bilateral transmigration of mandibular canine is even much rarer. Treatment can be orthodontic or surgical. Orthodontic treatment is very cumbersome. Here we are reporting a case of a bilateral transmigration of canines which was treated surgically, with great results. Also we are giving a brief review of literature. Key words; abgel, b...

In this paper, we present a microfluidic platform for the study of cancer cell transmigration and anti-cancer drug screening. The device consists of an array of microchannels with dimensions close to the capillaries on the cellular barriers, while a thin glass coverslip is used as the substrate to enable high resolution imaging of cell dynamics during cancer cell transmigration. We have investi...

Transmigration through the endothelium is a key step in the immune response. In our recent work, the mechanical properties of the subendothelial matrix and biophysical state of the endothelium have been identified as key modulators of leukocyte trans-endothelial migration. Here, we demonstrated that neutrophil contractile forces and cytoskeletal dynamics also play an active biophysical role dur...

The recruitment of blood leukocytes across the endothelium to sites of tissue infection is central to inflammation, but also promotes chronic inflammatory diseases. A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane molecular scissor that is implicated in leukocyte transmigration by proteolytically cleaving its endothelial substrates. These include VE-cadherin, a homo...

Leukocyte transmigration is mediated by endothelial cell (EC) junctional molecules, but the associated mechanisms remain unclear. Here we investigate how intercellular adhesion molecule-2 (ICAM-2), junctional adhesion molecule-A (JAM-A), and platelet endothelial cell adhesion molecule (PECAM-1) mediate neutrophil transmigration in a stimulus-dependent manner (eg, as induced by interleukin-1beta...

ICAM-2 has been implicated in leukocyte transmigration in vitro, but there is little in vivo evidence to support this. To address this, neutrophil migration was investigated in ICAM-2-deficient mice (KO) and in wild-type (WT) mice treated with an anti-ICAM-2 blocking monoclonal antibody (mAb) (3C4). In a peritonitis model, IL-1beta-induced accumulation of neutrophils was significantly reduced i...

ICAM-2 has been implicated in leukocyte transmigration in vitro, but there is little in vivo evidence to support this. To address this, neutrophil migration was investigated in ICAM-2–deficient mice (KO) and in wild-type (WT) mice treated with an anti–ICAM-2 blocking monoclonal antibody (mAb) (3C4). In a peritonitis model, IL-1 –induced accumulation of neutrophils was significantly reduced in m...

A vast amount of work has been dedicated to the effects of shear flow and cytokines on leukocyte transmigration. However, no studies have explored the effects of substrate stiffness on transmigration. Here, we investigated important aspects of endothelial cell contraction-mediated neutrophil transmigration using an in vitro model of the vascular endothelium. We modeled blood vessels of varying ...