transgenic (tg) mice are very important models of disease, and have been introduced to biological studies since 1982. they are used for understanding the pathobiology of different diseases, finding targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. many different types of tg mice are available as models for human disea...

Two recent reports in which transgene techniques were used to label specific cell classes in the mouse retina have opened the way to new methods of studying retinal signal processing.

abstract background: determination of transgenic embryos from non transgenic embryos sibling is an important step in producing homozygous transgenic mice. these steps need by pcr or southern blotting followed extraction of dna, but both techniques require skill and consume time. objective: the aim of this study was simulation of high accuracy method using novel enhanced green fluorescent protei...

Alexander C. Jackson, Chen Liu, Makoto Fukuda, Michael Lazarus and Laurent Gautron* 1 Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA 2 Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA 3 Baylor College of Medicine, Childrens Nutrition Research Ct, Houston, TX, USA 4 Internat...

Sugarcane is a unique crop with the ability to accumulate high levels of sugar and is a commercially viable source of biomass for bioelectricity and second-generation bioethanol. Water deficit is the single largest abiotic stress affecting sugarcane productivity and the development of water use efficient and drought tolerant cultivars is an imperative for all major sugarcane producing countries...

The technique of introducing new genetic material into the germline of mammals has been a major development in biotechnology over the last decades. ”Transgenic animals“ are animals whose chromosomes contain stable, integrated copies of exogenous genes, additional copies of endogenous genes or gene constructs. They are frequently created by two different techniques: microinjection of DNA into th...

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