نتایج جستجو برای: transforming growth factor beta1
تعداد نتایج: 1481482 فیلتر نتایج به سال:
مقدمه: آسیب های بافت غضروف در کشورهای پیشرفته، مهم ترین علت ناتوانی در سالمندان است. علاوه بر آن، غضروف مفصلی توانایی محدودی در ترمیم دارد. روش های درمانی رایج قادر به ترمیم این آسیب ها نمی باشد؛ چرا که منجر به ایجاد بافت فیبروزی در غضروف می شوند. سلول درمانی، یکی از روش های درمان است که در آن، سلول های بنیادی با کمک مهندسی بافت می توانند به کندروسیت تمایز یابند و جهت دستیابی به این هدف، از عوا...
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis within skeletal muscle. In this study, we further explored the potential role of myostatin in skeletal muscle fibrosis, as well as its interaction with both transforming growth factor-beta1 and decorin. We discovered that myostatin stimu...
BACKGROUND Dupuytren's Disease (DD) is a debilitating contractile fibrosis of the palmar fascia characterised by excess collagen deposition, contractile myofibroblast development, increased transforming growth factor-beta levels and beta-catenin accumulation. The aim of this study was to determine if a collagen-enriched environment, similar to in vivo conditions, altered beta-catenin accumulati...
Transforming growth factor-beta1 (TGF-beta1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-beta1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the clinical significance of serum TGF-beta1 level in pediatric patients. The diagnostic application of th...
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