glutathione s-transferases (gsts) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. the human gsts are divided into four classes: alpha, mu, pi and theta. previous studies indicated that the absence of the glutathione s-transferase m1 (gstm1) protein correlated with an increased risk of developing some types of cancers. association between spe...

background: endometriosis is one of the most common gynecologic disorders. it is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. there is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. glutathione-s-transferase m1 (gstm1) is one of the genes involved in detoxification of endogenous ...

OBJECTIVE We investigated the role of the glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms and potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients. PATIENTS AND METHODS A hospital-based case-control study of bladder cancer in men comprised 143 histologically confirmed cases and 114 age-matched male controls. Delet...

The clathrin-mediated sequestration pathway is used by non-G protein-coupled receptors (e.g., transferrin receptors) and a large number of G protein-coupled receptors, including beta-2 adrenoceptors and various muscarinic acetylcholine receptor (mAChR) subtypes. Recently, the ubiquitously expressed small GTPase RhoA has been implicated as a negative regulator of transferrin receptor internaliza...

BACKGROUND The contribution of the metal components of particulate pollutants to acute respiratory effects has not been adequately evaluated. Moreover, little is known about the effects of genetic polymorphisms of xenobiotic metabolism on pulmonary function. OBJECTIVES This study was conducted to assess lung function decrement associated with metal components in particulate pollutants and gen...

In order to clarify the expression of cytochrome P450 and glutathione S-transferase in human esophagus, 41 samples of human esophagus with squamous-cell carcinoma were investigated by immunoblot analysis and enzyme assays. Cytochrome P450 1A2/1 was clearly expressed in microsomes, and the amount in samples with tumorous tissue was significantly greater than that in samples without tumourous tis...

The sequence and exon-intron structure of the human class mu GSTM3 glutathione transferase gene and its orientation with respect to the remainder of the human class mu GSTM gene cluster were determined. The GSTM3 gene is 2847 bp long and is thus considerably shorter than the other class mu genes in the cluster, which range in size from 5325 to 7212 bp. Outside the protein-coding region, the GST...