multiple sclerosis (ms) is an inflammatory demyelinating and neurodegenerative disorder of  the  central  nervous  system (cns), which mainly affects  young adults. activated t lymphocytes promote the neuro-inflammatory cascade of ms by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. t  lymphocytes may trigger the inflammation, which in turn leads to axonal...

Background: Regulatory T cells (T-regs) have an important role in cancer by suppression of protective antitumor immune responses. Regulatory T cells express the forkhead/winged helix transcription factor (FOXP3) and OX40 molecules which have important regulatory roles in the immune system. Objective: To evaluate FOXP3 and OX40 transcripts in the peripheral blood mononuclear cells of women with ...

Background: Euphorbia plants are traditionally used in folk medicine for infections, inflammation, and cancer. Objectives: To investigate the effects of the butanolic extracts of Euphorbia micorociadia and Euphorbia osyridea on specific transcription factors and cytokines expression of T cell subsets. Methods: Activated mouse splenocytes were cultured in the presence of non-cytotoxic concentrat...

background: regulatory t cells (t-regs) have an important role in cancer by suppression of protective antitumor immune responses. regulatory t cells express the forkhead/winged helix transcription factor (foxp3) and ox40 molecules which have important regulatory roles in the immune system. objective: to evaluate foxp3 and ox40 transcripts in the peripheral blood mononuclear cells of women with ...

Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...

Objective(s): Multiple sclerosis (MS) is considered as a chronic type of an inflammatory disease characterized by loss of myelin of CNS.Recent evidence indicates that Interleukin 17 (IL-17)-producing T helper cells (Th17 cells) population are increased and regulatory T cells (Treg cells) are decreased in MS. Despite extensive research in understanding the mechanism of Th17 and Treg differentiat...

all-trans retinoic acid (atra), as an active metabolite of vitamin a, has been shown to affect immune cells. this study was performed to evaluate the effect of atra on viability, proliferation, activation and lineage-specific transcription factors of cd4+ t cells. cd4+ t cells were  separated  from  heparinized  blood  of  healthy  donors  and  were  cultured  in conditions, some with, some wit...

The transcription factor Foxp3 dominantly controls regulatory T (Treg) cell function, and only its continuous expression guarantees the maintenance of full Treg cell-suppressive capacity. However, transcriptional regulators maintaining Foxp3 transcription are incompletely described. Here, we report that high E47 transcription factor activity in Treg cells resulted in unstable Foxp3 expression. ...

Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on fetus and pregnancy outcomes. This study aimed at evaluating the effect of 1,25VitD3 on specific transcription factor and markers of Tregs and Th17 cells in the PBMCs of women with URPL as a case group and the PBMCs of healthy women as a control group. Methods: Samples from 20 non-pregnant patients with...

Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4+ T cells wit...