mucosa-adhesive gels can be used as a useful mean of delivering drugs to or via mucosal membranes, and in particular buccal mucosa. carbomers are among the best mucosa-adhesive materials known. the aim of this study was to compare the results obtained from the mucosa-adhesive strength of aqueous gels containing carbomers, either alone or in combination, to the data obtained from assessing the d...

Neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson’s (PD), are common age-related diseases responsible for high disability. Disease-modifying treatments AD PD still lacking, but symptomatic therapies available, although limited by difficult administration patients’ scarce compliance at later stages. Transbuccal Drug Delivery Systems (TDDSs) include chemical-physics biot...

TRANSDERMAL AND TRANSBUCCAL DELIVERY OF LIDOCAINE AND NICOTINE: COMBINED EFFECTS OF IONTOPHORESIS AND CHEMICAL ENHANCERS by Ran Wei This study focused on the effects of iontophoresis and chemical enhancers on drug release. The transport of Lidocaine HCl (LHCl) and Nicotine Hydrogen Tartrate (NHT) through the skin and mucosa was evaluated for potential clinical applications. These two potential ...

the main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of methocel® k15, ethocel® standard 7fp premium, eudragit ® rs100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. risperidone floating tablets were formulated by wet granulati...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...