نتایج جستجو برای: tpi

تعداد نتایج: 898  

Journal: :Journal of cell science 2013
Bartholomew P Roland Kimberly A Stuchul Samantha B Larsen Christopher G Amrich Andrew P Vandemark Alicia M Celotto Michael J Palladino

Triosephosphate isomerase (TPI) is a glycolytic enzyme that converts dihydroxyacetone phosphate (DHAP) into glyceraldehyde 3-phosphate (GAP). Glycolytic enzyme dysfunction leads to metabolic diseases collectively known as glycolytic enzymopathies. Of these enzymopathies, TPI deficiency is unique in the severity of neurological symptoms. The Drosophila sugarkill mutant closely models TPI deficie...

Journal: :The EMBO journal 1997
J Zhang L E Maquat

Nonsense codons upstream of and including position 192 of the human gene for triosephosphate isomerase (TPI) have been found to reduce the abundance of TPI mRNA to approximately 25% of normal. The reduction is due to the decay of newly synthesized TPI mRNA that co-purifies with nuclei. TPI mRNA that co-purifies with cytoplasm is immune to nonsense-mediated decay. Until now, a nonsense codon at ...

Journal: :PLoS ONE 2006
Markus Ralser Gino Heeren Michael Breitenbach Hans Lehrach Sylvia Krobitsch

Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disorder caused by various mutations in the gene encoding the key glycolytic enzyme TPI. A drastic decrease in TPI activity and an increased level of its substrate, dihydroxyacetone phosphate, have been measured in unpurified cell extracts of affected individuals. These observations allowed concluding that the different mutati...

Journal: :PLoS genetics 2016
Bartholomew P Roland Alison M Zeccola Samantha B Larsen Christopher G Amrich Aaron D Talsma Kimberly A Stuchul Annie Heroux Edwin S Levitan Andrew P VanDemark Michael J Palladino

Triosephosphate isomerase (TPI) deficiency is a poorly understood disease characterized by hemolytic anemia, cardiomyopathy, neurologic dysfunction, and early death. TPI deficiency is one of a group of diseases known as glycolytic enzymopathies, but is unique for its severe patient neuropathology and early mortality. The disease is caused by missense mutations and dysfunction in the glycolytic ...

Journal: :Cancer research 1984
Y Nishida H Sumi H Mihara

A thiol protease inhibitor (TPI) was found in culture media of human malignant melanoma cells (Bowes) at 1.5 to 2.3 units/day/flask (full sheet, 75 sq cm). This amount well exceeded that for cultured nonmalignant cells (human fetal lung fibroblasts). In the intracellular region of the melanoma cells, TPI activity was localized mainly in the cytosol fraction. The difference in specific activitie...

Journal: :Plant physiology 2004
Jorge A Zavala Aparna G Patankar Klaus Gase Dequan Hui Ian T Baldwin

Evidence for the in planta defensive function of trypsin protease inhibitors (TPIs) comes from observations of enhanced herbivore resistance after heterologous TPI expression or the manipulation of signal cascades that activate numerous defense responses, including TPI production; no studies have altered the expression of an endogenous pi gene to examine defensive function. We isolated two gene...

Journal: :CoRR 1997
Ehud Reiter Liesl Osman

Tailored patient information (TPI) systems are computer programs which produce persoualised heath-information material for patients. TPI systems are of growing interest to the natural-language generation (NLG) community; many TPI systems have also been developed in the medical community, usually with mail-merge technology. No matter what technology is used, experience shows that it is not easy ...

2009
Hiromi Furuya Reiko Ikeda

The glycolytic enzyme triosephosphate isomerase (TPI; EC 5.3.1.1) of Staphylococcus aureus is a candidate adhesion molecule for the interaction between the bacterium and the fungal pathogen Cryptococcus neoformans. TPI may recognize the mannan backbone of glucuronoxylomannan (GXM) of C. neoformans. We purified TPI from extracts of S. aureus surface proteins to investigate its binding by surface...

2014
Carolina Trujillo Antje Blumenthal Joeli Marrero Kyu Y. Rhee Dirk Schnappinger Sabine Ehrt

ABSTRACT Triosephosphate isomerase (TPI) catalyzes the interconversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P). This reaction is required for glycolysis and gluconeogenesis, and tpi has been predicted to be essential for growth of Mycobacterium tuberculosis. However, when studying a conditionally regulated tpi knockdown mutant, we noticed that depletion of TPI ...

Journal: :Stroke 2012
Peter McMeekin Darren Flynn Gary A Ford Helen Rodgers Richard G Thomson

BACKGROUND AND PURPOSE This study aimed to test the explanatory qualities of the Stroke-Thrombolytic Predictive Instrument (S-TPI) when applied to patients treated in routine practice. METHODS S-TPI predictions were compared with observed outcomes in terms of normal/near-normal (modified Rankin Scale score, ≤1) and catastrophic outcome (modified Rankin Scale score, ≥5) at 3 months. Logistic r...

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