نتایج جستجو برای: toxicogenetics
تعداد نتایج: 24 فیلتر نتایج به سال:
1Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Research Foundation, University of Cincinnati College of Medicine, OH; 2Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands; 3Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; and 4Department of Toxicogenetics, Leiden University Medical ...
Departments of Genetics, Pathology, Radiation Oncology, Medical Oncology and Cancer Genomics Center Netherlands, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands Departments of Toxicogenetics and Human Ge...
Fernando PG Silva, Sigrid MA Swagemakers, Claudia Erpelinck-Verschueren, Bas J Wouters, Ruud Delwel , Harry Vrieling, Peter van der Spek, Peter JM Valk & Micheline Giphart-Gassler 1 Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands, Departments of 2 Bioinformatics, 3 Cell Biology & Genetics and Hematology, Erasmus University Medical Center, Rotterdam, The N...
The response to drugs and environmental chemicals varies with genotype. Some patients react well to drugs, while others may not benefit, or may even respond adversely. Individuals also experience different reactions to environmental agents, such as allergens. The sequencing of the human genome and the large-scale identification of genome polymorphisms have provided opportunities for understandi...
*Departments of Clinical Neurosciences and Cell Biology & Anatomy, Hotchkiss Brain Institute, ◊Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, T2N4N1, Canada. ♦ Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 21 Stockholm, Sweden. ^Leiden University Medical Center, Department of Toxicoge...
Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can a...
Glutathione transferase enzymes (GSTs) catalyze reactions in which electrophiles are conjugated to the tripeptide thiol glutathione. While many GST-catalyzed transformations result in the detoxication of xenobiotics, a few substrates, such as dihaloalkanes, undergo bioactivation to reactive intermediates. Many molecular epidemiological studies have tested associations between polymorphisms (esp...
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