The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016. [...].

It is quite evident that microbial (bacteria or fungi) crude extracts contain several important bioactive compounds and some have already shown their therapeutic activity. Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule. Moreover, some of the mechanisms of actions of few bioactive compounds have not been identified so far. Hence, ex...

Changes in a patient’s patterns of cocaine use are generally considered an important outcome measure of treatment efficacy. Other treatment outcome measures are important as well, but if a treatment does not stop or significantly decrease the intensity of a cocaine addict’s cocaine use, many would question the treatment’s efficacy. Examination of a patient’s urine for evidence of cocaine or coc...

New stability indicating chromatographic methods have been developed for estimation of Assay and Impurities of Docetaxel in Docetaxel injection for evaluation of pharmaceutical quality. With this method, the process related impurities and degradants are well separated from the peaks due to placebo. The relative retention times and relative response factors of the known impurities have been esta...

Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 micrograms/24 h, respectively. The res...

Traditional methods for assessing dietary exposure can be unreliable, with under reporting one of the main problems. In an attempt to overcome such problems there is increasing interest in identifying biomarkers of dietary intake to provide a more accurate measurement. Metabolomics is an analytical technique that aims to identify and quantify small metabolites. Recently, there has been an incre...

The Stenotrophomonas genus shows great adaptive potential including resistance to multiple antimicrobials, opportunistic pathogenicity, and production of numerous secondary metabolites. Using long-read technology, we report the sequence of a plant-associated Stenotrophomonas strain originating from the citrus phyllosphere that displays a copper resistance phenotype.

The enzyme d-ribonuclease is antigenic. Antisera, prepared by three different methods, reacted against antigen dilutions up to one million. Apparently the homologous antiserum, when combined with the d-ribonuclease inhibited the activity of the enzyme from 10 to 30 per cent.