BACKGROUND Excessive fibrin deposition within the inflamed joints of rheumatoid arthritis (RA) patients suggests that local fibrinolysis is inefficient, which seems to be in contrast with the observed increased levels of urokinase type plasminogen activator (u-PA). Thrombin-mediated inactivation of single chain u-PA (scu-PA) into an inactive form called thrombin-cleaved two chain u-PA (tcu-PA/T...

OBJECTIVE To describe two innovative practice models that expand pharmacy services within a nursing facility's transitional care unit (TCU) to meet the needs of patients transitioning to subacute or community care. SETTING TCU in a hospital-based vs. a community-based facility. PRACTICE DESCRIPTION The two TCUs involved in these practices differ in that one is hospital-owned and the other i...

The Fourth (4) Annual Student Research Symposium (SRS) for graduate and undergraduate students majoring in science, engineering, and mathematics will be conducted at Texas Christian University (TCU) on Thursday and Friday, April 20-21, 2006. The Symposium is designed to offer a mentored research experience to students in the TCU College of Science and Engineering. The Symposium has been success...

Stage-2 CoCl2-GIC is a spin ceramic and shows hierarchical successive transitions at Tcu (= 8.9 K) and Tcl (= 7.0 K) from the paramagnetic phase into an intra-cluster (two-dimensional ferromagnetic) order with inter-cluster disorder and then to an inter-cluster (three-dimensional antiferromagnetic like) order over the whole system. The nature of the inter-cluster disorder was suggested to be of...

OBJECTIVE To determine whether providing elderly alternate level of care (ALC) patients with interdisciplinary care on a transitional care unit (TCU) achieves better clinical outcomes and lowers costs compared with providing them with standard hospital care. DESIGN Before-and-after structured retrospective chart audit. SETTING St Joseph's Hospital in Comox, BC. PARTICIPANTS One hundred th...

The activation of plasminogen at the surface of fibrin by single-chain urokinase-type plasminogen activator (scu-PA) was investigated using recombinant forms of a plasmin-resistant mutant of scu-PA, rscu-PA-Glu158, and an inactive catalytic site mutant of human plasminogen, rPg-Ala741. Conversion of cleavable 125I-labeled single-chain proteins to their two-chain forms, was quantitated by radioi...