the topical delivery of non-steroidal anti-inflammatory drugs (nsaids) such as ibuprofen has been explored as a potential method of avoiding the first pass effects and the gastric irritation, which may occur when used orally. ibuprofen is formulated into many topical preparations to reduce the adverse effects and simultaneously avoid the hepatic first-pass metabolism as well. however, it is dif...

Executive Board, AAP mor appearance in young women. New Eng. J. Med., 284:878, 1971. 2. Greenwald, P., Barlow, J. J., Nasca, P. C., and Burnett, W. S. : Vaginal cancer after maternal treatment with synthetic estrogens. New Eng. J. Med., 285:390, 1971. 3. Herbst, A. L., Ulfelder, H., and Poskanzer, D. C.: Registry of clear-cell carcinoma of genital tract in young women. New Eng. J. Med., 285:407...

PURPOSE In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. METHODS Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these prep...

Evidence-Based Answer Topical silver should not be used for treatment of nonburn wounds because it does not hasten healing. (Strength of Recommendation [SOR]: A, based on a systematic review of randomized controlled trials [RCTs].) Medical-grade topical honey can be used to reduce healing time for partial-thickness burns, but it produces no effect on lacerations, surgical wounds, chronic wounds...

The purpose of this study is to elucidate the physical properties of various commercially available topical corticosteroid preparations. We compared comfort after application and the physical properties affecting topical application among brands of commercially available topical corticosteroid ointments and creams to identify factors affecting quality of life after application. We investigated ...