نتایج جستجو برای: tolterodine
تعداد نتایج: 306 فیلتر نتایج به سال:
OBJECTIVES To compare the efficacy of tolterodine plus simplified bladder training (BT) with tolterodine alone in patients with an overactive bladder. PATIENTS AND METHODS In a multicentre, single-blind study at 51 Scandinavian centres, 505 patients aged >or= 18 years with symptoms of urinary frequency (>or= 8 micturitions/24 h) and urgency, with or without urge incontinence, were randomized ...
We present a case of acute tolterodine overdose with anticholinergic toxidrome including drowsiness, confusion and pyrexia. Tolterodine was commonly used in recent years for the treatment of overactive bladder syndrome. Experience with acute tolterodine poisoning was limited. The pharmacology, clinical use and side effects of tolterodine were reviewed. The clinical manifestations, toxicology an...
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for simultaneous quantification of tolterodine and its metabolite 5-hydroxy methyl tolterodine in rat plasma. Tolterodine-d6 and 5-hydroxy methyl tolterodine-d14 were used as internal standards (IS). Chromatographic separation was performed on Ascentis Express RP amide (50 mm×4.6 mm, 2.7 μm) column with an isocratic mobil...
Tolterodine, a new muscarinic receptor antagonist, is metabolized via two pathways: oxidation of the 5-methyl group and dealkylation of the nitrogen. In an attempt to identify the specific cytochrome P450 enzymes involved in the metabolic pathway, tolterodine was incubated with microsomes from 10 different human liver samples where various cytochrome P450 activities had been rank ordered. Stron...
BACKGROUND Overactive bladder (OAB)/ storage lower urinary tract symptoms (LUTS) have a high prevalence affecting up to 90% of men over 80 years. The role of sufficient therapies appears crucial. In the present review, we analyzed the mechanism of action of tolterodine extended-release (ER) with the aim to clarify its efficacy and safety profile, as compared to other active treatments of OAB/st...
BACKGROUND To assess the efficacy and safety of the herbal medicine, Weng-li-tong (WLT) as monotherapy or combined with tolterodine in women with overactive bladder (OAB). METHODS A prospective, randomized, single-blind multi-center trial was performed which included 182 OAB patients treated with either placebo (n = 26), WLT (n = 52), tolterodine (n = 52) or WLT plus tolterodine (n = 52). The...
Tolterodine is a muscarinic antagonist widely used in the treatment of urinary incontinence. Although tolterodine has not been reported to alter cardiac repolarization, it is chemically related to other muscarinic antagonists known to prolong cardiac repolarization. For this reason, we studied the effects of tolterodine on cardiac ion channels and action potential recordings. Using patch-clamp ...
Overactive bladder (OAB) is a common problem whose prevalence increases with advancing age and compromises health-relatedqualityoflife.TolterodinewasthefirstantimuscarinicdrugspecificallydesignedtotreatOAB. ThroughMEDLINE,wereviewedarticles,standardizationreportsandmeetingabstracts,publishedbetween2001and2011,ontheefficacy and tolerability of Tolterodine extended...
Objective: Tolterodine has proved effective for treating non-neurogenic overactive bladder in Paediatric patients but has been less well studied in children with neurogenic detrusor overactivity. The objective of the current study was to look for incremental benefits of tolterodine (if any) in patients who are already being treated with oxybutynin. Methods: Patients with neurogenic bladder who ...
Tolterodine is a new muscarinic receptor antagonist intended for the treatment of urinary urge incontinence and other symptoms associated with an overactive bladder. The in vivo metabolism of 14C-labeled tolterodine was investigated in rats, mice, and dogs by analysis of blood and urine samples, whereas in vitro metabolism studies were performed by incubation of [14C]tolterodine with mouse, rat...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید