This paper compares the efficacy of tolmetin, prednisolone, and placebo (vehicle only) in controlling post-cataract extraction inflammation in a double-blind trial involving 120 patients. Seventeen patients were excluded from analysis. The results of the 103 patients analysed showed that 94% of the prednisolone treated group was judged to have been successfully treated as compared with 53% of t...

A double-masked controlled clinical trial of 5% unpreserved tolmetin versus 0.5% prednisolone versus 0.9% saline in acute endogenous nongranulomatous anterior uveitis was carried out on 100 patients. 69% of the prednisolone-treated patients were judged "cured" at the end of the 3-week study. This is compared with a cure rate of 47% for the tolmetin-treated patients for 53% for the placebo (sali...

We previously reported that delta-9-tetrahydrocannabinol (delta-9-THC), the primary psychoactive constituent of Cannabis sativa, inhibited gastric motor activity and evoked bradycardia and hypotension upon its parenteral administration in the rat. As prostanoids are important mediators of the actions of cannabinoids, we hypothesized that the inhibitory gastric motor and cardiovascular effects o...

Carboxylic acids may be metabolized to acyl glucuronides and acyl-coenzyme A thioesters (acyl-CoAs), which are reactive metabolites capable of reacting with proteins in vivo. In this study, the metabolic activation of tolmetin (Tol) to reactive metabolites and the subsequent formation of Tol-protein adducts in the liver were studied in rats. Two hours after dose administration (100 mg/kg i.p.),...

aFaculty of pharmacy, International Aras Branch, Tabriz University of Medical Sciences, Tabriz, Iran. bDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz. cDepartment of Microbiology, Bonab Branch, Islamic Azad University, Bonab, Iran. dStudent Research Committee, Ardabil University of Medical Sciences, Ardabil, Iran. Copyright © 2017 by School of Pharmacy Shaheed Behes...

The occurrence of pharmaceuticals in the aqueous environment has been widely published but the fate of pharmaceutical residues in the environment continues to attract the attention of the scientific community. Due to the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs), this group of drugs is often detected and determined in surface waters, influent and effluent wastewaters, and...