نتایج جستجو برای: tolbutamide

تعداد نتایج: 836  

Journal: :iranian journal of pharmaceutical research 0
xiangjun qiu department of pharmacology,medical college of henan university of science and technology, aili fei the first affiliated hospital of wenzhou medical college zhisheng xu the second affiliated hospital of wenzhou medical college zhe wang the first affiliated hospital of wenzhou medical college, wenzhou 325000, china. xianqin wang analytical and testing center of wenzhou medical college, wenzhou 325000, china. lufeng hu the first affiliated hospital of wenzhou medical college, wenzhou 325000, china.

a “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome p450 enzymes in one session. some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. our presented work was to aim on the influence of bupropion on rat cytochrome p450-mediated metabolism of tolbutamide. the biotransformation rates of tolbutam...

Journal: :Chemical & pharmaceutical bulletin 2000
K Kimura F Hirayama H Arima K Uekama

The effects of storage on the crystallization, dissolution and absorption of tolbutamide from amorphous tolbutamide-2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) complex were investigated, in comparison with those of polyvinylpyrrolidone (PVP) solid dispersion. The amorphous solid complex of tolbutamide with HP-beta-CyD and the solid dispersion of tolbutamide with PVP were prepared by a spray...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2000
K Komatsu K Ito Y Nakajima S i Kanamitsu S Imaoka Y Funae C E Green C A Tyson N Shimada Y Sugiyama

Drug-drug interactions between tolbutamide and sulfonamides have extensively been reported. We attempted to predict the in vivo interaction between tolbutamide and sulfonamides from the in vitro metabolic inhibition studies. The inhibition constant (K(i)) was derived from the inhibitory effects of eight sulfonamides (sulfaphenazole, sulfadiazine, sulfamethizole, sulfisoxazole, sulfamethoxazole,...

2013
Haw-Wen Chen Chin-Shiu Huang Pei-Fen Liu Chien-Chun Li Chiung-Tong Chen Cheng-Tzu Liu Jia-Rong Chiang Hsien-Tsung Yao Chong-Kuei Lii

Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes in rat liver and determined whether modulation of these enzymes changed the pharmacokinetics of tolbutamide. Rats were intragastrically dosed with 2...

A “cocktail”of several probe drugs is often used to evaluate metabolic activity of multiple cytochrome P450 enzymes in one session. Some interactions among probe drugs can appear and may impact the rate of biotransformation of other ones. Our presented work was to aim on the influence of bupropion on rat cytochrome P450-mediated metabolism of tolbutamide. The biotransformation rates of tolbutam...

Journal: :American journal of physiology. Endocrinology and metabolism 2000
C Schöfl J Börger T Mader M Waring A von zur Mühlen G Brabant

Arginine vasopressin (AVP), bombesin, and ACh increase cytosolic free Ca(2+) and potentiate glucose-induced insulin release by activating receptors linked to phospholipase C (PLC). We examined whether tolbutamide and diazoxide, which close or open ATP-sensitive K(+) channels (K(ATP) channels), respectively, interact with PLC-linked Ca(2+) signals in HIT-T15 and mouse beta-cells and with PLC-lin...

Journal: :Indian journal of physiology and pharmacology 1998
S Satyanarayana Y S Krishnaiah B K Rao

The study was conducted to find the involvement of Nitric Oxide (NO) using L-arginine, a NO precursor and NG-methyl L-arginine a nitric oxide synthase inhibitor on tolbutamide activity in normal rabbits. L-arginine (25-300 mg/kg, body weight, oral) produced transient and dose dependent hypoglycaemia. When combined with tolbutamide (40 mg/kg, oral) it produced early and prolonged action. The eff...

Journal: :Diabetes 2007
Jocelyn de Heer Jens J Holst

Glucagon-like peptide (GLP)-1 mimetics have been reported to cause hypoglycemia when combined with sulfonylureas. This study investigated the impact of tolbutamide on the glucose dependence of the GLP-1-mediated effects on insulin, glucagon, and somatostatin secretion in the in situ perfused rat pancreas. At 3 mmol/l glucose, GLP-1 alone did not augment insulin secretion, whereas tolbutamide al...

Journal: :American journal of physiology. Endocrinology and metabolism 1998
A Rostami-Hodjegan S R Peacey E George S R Heller G T Tucker

Tolbutamide is used increasingly as an investigative tool in in vivo studies of the physiology of glucose tolerance. Its hypoglycemic effect in nondiabetic subjects is widely variable, reflecting possible variability in its pharmacokinetics, an insulinergic response, an extrapancreatic effect of the drug, or the hypoglycemic effect of insulin itself. Using population-based modeling, we have inv...

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