1. dept. of biology, science and research branch, islamic azad university, tehran, iran 2. national science foundation (insf), tehran, iran 3. dept. of genetics, tehran medical sciences branch, islamic azad university, tehran, iran                                   corresponding author: mrhrdad hashemi, phd; associate professor of molecular genetics tel: (+98) 2122006664 email: mhashemi@iautmu....

The expression of Triggering Receptor Expressed on Myeloid cells ( TREM)-1 has been described as a predictive marker for anti-Tumor Necrosis Factor (TNF)-? monoclonal antibody (mAb) therapy responsiveness in patients with inflammatory bowel disease (IBD). Here we investigated TREM-1 specifically CD14+ monocytes relation to anti-TNF response. pretreatment levels Crohn’s (CD) were outcome mAb the...

Tumor necrosis factor-alpha (TNF-α) plays an important role in liver inflammation. CD40-CD40 ligand (CD40-CD40L) is a key receptor–ligand signaling pair involved the adaptive immune response and pathogenesis of autoimmune diseases. In mice, CD40 activation leads to sickness behavior syndrome (SBS) comprising weight loss, sleep disruption depression, which can be blocked by administration TNF-in...

Abstract The intestinal microbiota contributes to gut immune homeostasis, where short-chain fatty acids (SCFAs) function as the major mediators. We aimed elucidate immunomodulatory effects of acetate, propionate, and butyrate. With that in mind, we sought characterise expression SCFA receptors transporters well SCFAs’ impact on activation different cells. Whereas all three SCFAs decreased tumou...

introduction: daphne species has both pharmaceutical applications and anti tumor activity. it has been shown that the extract of daphne mucronata is effective in decreasing the size of breast adenocarcinoma in rats. we investigated the mechanism of action and the effects of the extract on tnf-a and tnf-a receptors on cultured human monocytes. material and methods: the breast tumors were induced...