Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play role in many physiological functions, including the immune response. An imbalance between activity MMPs and their tissue inhibitors (TIMPs) has been proposed pathophysiology different autoimmune disorders. We aimed to assess plasmatic levels MMP-2, MMP-9, TIMP-1 -2 patients with chronic inflammatory demyelin...

background and purpose: skin cancer is one of the most common types of cancer. several studies suggest a high incidence of skin cancer in most countries. timp-2 is the tissue inhibitor of matrix metalloproteinase and exist in both cancer and normal cells. the aim of this study was to investigate the expression of timp-2 gene in patients with skin cancer and evaluating the association between th...

background: one of the most major obstacles of ovarian tissue vitrification is suboptimal developmental competence of follicles. matrix metalloproteinases 2 (mmp-2) and 9 (mmp-9) and their tissue inhibitors timp-1 and timp-2 are involved in the remodeling of the extracellular matrix in the ovaries. objective: this study aimed to evaluate the expression of mmp-2, mmp-9, timp-1, and timp-2 genes ...

background: colorectal cancer is one of the most important causes of morbidity and mortality in the world. it has been suggested that tissue inhibitor of metalloproteinase-1 (timp-1) plays a particular role in cancer promotion. the objective of the present study was to compare the effect of repeated measurement of carcinoembryonic antigen (cea) and timp-1 plasma levels in a follow-up response t...

angiotensin ii, the main component of the renin-angiotensin system, is associated with cardiovascular diseases such as hypertension, vascular remodeling and inflammation. remodeling process results from dysregulation of matrix metalloproteinases (mmps) and their tissue inhibitors (timps). mmps are considered as important target genes for angiotensin ii. the aim of this study was to determine th...

conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...

background: considering the role of matrix metalloproteinase-3 (mmp-3) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in the pathogenesis of periodontitis, the present study is to estimate the levels of mmp-3 and timp-1 in gingival crevicular fluid (gcf) in periodontal health, disease and to evaluate the effect of periodontal therapy on mmp-3 and timp-1 concentrations in gcf. mater...

The analysis of the balance elastase (MMP-2, MMP-9) and TIMP-4 was performed in order to determine their involvement pathogenesis NEC. A progressive duration NEC with sepsis is accompanied by increased serum concentrations MMP-9, MMP-2 TIMP-4. Increases MMP-2>503 ng/ml, MMP-9>812 ng/ml TIMP-4>1404 can be regarded as statistically significant predictors fatal outcome proposed method for...