Royal College of Veterinary Surgeons 382 Awards available 382 Letters 382 Liver biopsy in ragwort poisoning (C. S. Lombardo de Barros and others) 382 Serological Classification of Pasteurella multocida (G. R. Carter) 382 Paratuberculosis in dairy cattle (M. J. Prince) 383 A new coccidial stage (M. W. Gregory and others) 383 Statistics and common sense (M. Hugh-Jones) (A. J. Proud) 383 When to s...

Epigenetic changes may be causal in the ageing process and may be influenced by diet, providing opportunities to improve health in later life. The aim of this review is to provide an overview of several areas of research relevant to this topic and to explore a hypothesis relating to a possible role of epigenetic effects, mediated by sirtuin 1, in the beneficial effects of dietary restriction, i...

The inhibition of the soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of cardiovascular, inflammation and other disorders. A piperazino functionality as the tertiary pharmacophore remarkably improved the drug-like profile of the 1,3-disubstituted urea sEH inhibitors. However, the potency was more dependent on the overall best balance of the hydrophilicity and lipophi...

Health benefits or advocated health benefits of long-chain (LC) n-3 PUFA are better known by medical doctors as well as by consumers, so that consumption increases. In addition, the development of aquaculture requires more fishmeal and fish oil. Humanisation of care of companion animals is also associated with addition of LC n-3 PUFA in pet foods. The risk of the increased demand for LC n-3 PUF...

252x252 (left) and 384x384 (right). SAP-EPI and RS-EPI datasets were acquired in equivalent scan times of 1:24min/volume. Fig 3: (a) Scan-timenormalized noise maps (i.e. accounting for the maximum number of slices) of distortion-correctedSAP-EPI and RS-EPI calculated over six b = 0 scans (matrix size=384). (b) A RSEPI 384 image is blurred by a Gaussian kernel to achieve the same SNR as SAPEPI, ...

Stanley Crouch, Kansas City Lightning: The Rise and Times of Charlie Parker. New York: HarperCollins, 2013. 384 pp. ISBN 978-0-06-200559-5 (hbk). $37.86.

Despite the fact that much progress has been made recently in the development of targeted covalent inhibitors (TCIs), their pharmacokinetics (PK) have not been well characterized in the light of extrahepatic clearance (CLextH) by glutathione (GSH)/glutathione S-transferase (GST)-dependent conjugation attributable to the unique electrophilic structure (e.g., acrylamide moiety) of TCI compounds. ...

Background: Food intake fluctuates throughout the menstrual cycle; it is greater during the early follicular and luteal phases than in the late follicular (periovulatory) phase. Ovarian steroids can influence brain areas that process food-related information, but the specific contribution of individual hormones and the importance of the prandial state remain unknown. Objective: The objective wa...

The calcium ion regulatesmanyaspects of neuronalmigration,which is an indispensable process in the development of the nervous system. Calmodulin (CaM) is a multifunctional calcium ion sensor that transduces much of the signal. To better understand the role of Ca-CaM in neuronal migration, we investigated mouse precerebellar neurons (PCNs), which undergo stereotyped, long-distance migration to r...

The functional properties of T and B lymphocytes and the nature of their participation in the immune response have been elucidated to a large extent in recent years (1). Evidence of functional heterogeneity within the T-cell compartment has been garnered by utilizing surface markers which distinguish subsets of cells (2). Although B cells also carry distinctive surface markers, evidence of func...