The protein tyrosine phosphatase PTPN22 inhibits T cell activation by dephosphorylating some essential proteins in the receptor (TCR)-mediated signaling pathway, such as lymphocyte-specific kinase (Lck), Src family kinases Fyn, and phosphorylation levels of Zeta-chain-associated kinase-70 (ZAP70). For first time, we have successfully produced CS transgenic mice which activity is suppressed. Not...

Fucoxanthin is a natural carotenoid obtained from seaweed which exhibits antioxidant properties. This research aimed to assess whether fucoxanthin, immobilized on aluminum-silicon carrier particles, has toxic effect immune cells. The viability, proliferation, nitric oxide production and myeloperoxidase activity of thymocytes splenocytes mice in vitro were studied. It was shown that increased th...

background: there is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. this study aimed at determining the anti-apoptotic effect of oleuropein (ole) on dexamethasone-induced apoptosis of mouse thymocytes. method: mice were randomly divided to four groups as follow: dexamethasone (dex)-treated group (20 mg/kg;...

Abstract Central tolerance aims to limit the production of T lymphocytes bearing TCR with high affinity for self-peptide presented by MHC molecules. The accumulation thymocytes such receptors is limited negative selection or diversion into alternative differentiation, including regulatory cell commitment. A role orphan nuclear receptor NR4A3 in has been suggested, but its function this process ...

Background: There is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. This study aimed at determining the anti-apoptotic effect of Oleuropein (Ole) on dexamethasone-induced apoptosis of mouse thymocytes. Method: Mice ...

Eosinophils differentiate and mature in the thymus, outside of bone marrow, healthy individuals. Locally developed thymic eosinophils may contribute to maturation selection human thymocytes.

Foxp3+ Treg cells, which are crucial for maintenance of self-tolerance, mainly develop within the thymus, where they arise from CD25+ Foxp3- or CD25- cell precursors. Although it is known that infections can cause transient thymic involution, impact infection-induced thymus atrophy on (tTreg) development unknown. Here, we infected mice with influenza A virus (IAV) and studied thymocyte populati...

background: recent results have provided increasing evidence to support involvement of membrane damage in the mechanism of ionizing radiation induced killing of mammalian cells. these findings have stimulated renewed interest in evaluating the damage to membrane as a primary initiator in radiation-induced cell killing especially in apoptotic death. the present study was aimed to gain deeper ins...

The aim of the present study was to determine whether the sensitivity of thymocytes to X-ray radiation depends on their proliferative states and whether radiation impairs the maturation of donor-derived thymocytes in recipient thymus. We assigned 8-week-old C57BL/6J mice into three treatment groups: 1) untreated; 2) X-ray radiation; 3) X-ray radiation plus bone marrow transplantation with donor...