in the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. among the ligands tested, diacetyl-bis(n4-methylthiosemicarbazones) (atsm) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde bis(n4-methyl)thiosemicarbazone (ptsm) was shown to possess low toxicity (7% let...

INTRODUCTION It has been more than 22 years since the last case of smallpox was confirmed and 20 years since the World Health Organization declared that the global eradication of smallpox had been achieved. The subsequent discontinuation of vaccination against smallpox (with vaccinia virus [VV] vaccine) has rendered most humans vulnerable to smallpox infection. The recent outbreak of monkeypox ...

      In the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. Among the ligands tested, diacetyl-bis(N4-methylthiosemicarbazones) (ATSM) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde Bis(N4-methyl)thiosemicarbazone (P...

SUMMARY The drugs [1-ß-D-arabinofuranosylcytosine (ara-C), hy-droxyurea (HU), 5-hydroxy-2-formylpyridine thiosemicar-bazone (5-HP), and camptothecin sodium salt (camptothecin)] considered in this paper markedly inhibit DNA synthesis and are maximally cytotoxic to cells in S phase. In these studies, high-specific-activity thymidine-3H (HSA-TdR-3H) was used as a control compound which killed cel...

Isoji Sasagawa, MD, Department of Urology, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata-shi, Yamagata 990-23 (Japan) pressure, bicarbonate and base excess. Sodium and potassium were determined by flame photometry. Chloride was measured by amperometric titration. BUN was determined by a diacetylmonoxime-thiosemicar-bizide reaction and creatinine was estimated with a modifie...