In a quest to identify novel compounds targeting HCV viral replicase, we evaluated a new series of 4-thiazolidinone derivatives (18 compounds). Our in vitro NS5B RdRp inhibition analysis with a series of 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid (2-(5-nitro-2-furyl/substituted phenyl)-4-thiazolidinone-3-yl) amides (1-7) yielded IC50 values ranging between 45-75 microM. Of these, lead c...

In recent years, there has been a rising interest in researching and finding new antimicrobial agents from various sources to fight against microbial infectious pathogens. Therefore, a greater attention has been paid to synthesize new molecules. In this regarding a straightforward two-step protocol for the synthesis of 2,3-disubstituted-4-thiazolidinone (4a-f) and 2,3disubstituted-5-methyl-4-th...

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively, from thiosemicarbazide, in satisfactory yields. Then, the synthesized compounds were submitted to evaluation against host cells infected with Toxoplasma gondii. The present studies showed that thiosemicarbazones 2 and 4-thiazolidinone derivatives 3 were effective against intracellular T. gondii.

Mixed ligand complexes of zinc (II) involving either mercaptyl thiazolidinone (1) [2-(2hydroxy benzoyl)-3-N-(2-mercaptyl)-1-Thiazolidin-4-one] or pyridine thiazolidinone (2) [ 2-(2hydroxy benzoyl-3-N-(2-Pyridinyl)-1-Thiazolidin-4-one] alone and along with thiourea have been obtained by partial or complete replacement of the strongly coordinated ammonia of ammine complex. All the products have b...

Thiazolidinone is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ralitoline as a potent anti-convulsant, etozoline as a antihypertensive, pioglitazone as a hypoglycemic agent and thiazolidomycin activity against streptomyces species proved potential of thiazolidinone moiety. This diversity in the biolog...

Mixed ligand complexes of copper (II), involving either Mercaptyl thiazolidinone (1) [2-(2hydroxy benzoyl)-3-N-(2-mercaptyl)-1-Thiazolidin-4-one] or Pyridine thiazolidinone (2) [ 2-(2hydroxy benzoyl-3-N-(2-Pyridinyl)-1-Thiazolidin-4-one] alone and along with Thiourea were synthesized by partial or complete replacement of the strongly coordinated ammonia of ammine complex. All the products have ...

A wide spectrum of biological activity and the possibility diverse chemical modification isatinderivatives prompts search for new highly active compounds as potential drugs among condensed noncondensedheterocyclic systems containing specified molecular "matrix". Studies 1,2,4-triazino[5,6-b]indoles,the precursors which are isatins, have shown prospect their use in treatment oncologicaldiseases....

Thiosemicarbazone and 4-thiazolidinone derivatives were synthesized in one and two step, respectively from thiosemicarbazide, in satisfactory yields. The structure of the compounds were elucidated by Elemental, IR, and NMR spectral data. The antibacterial activity of these compounds was tested by disc diffusion assay against two Gram-positive and two Gram-negative bacterie. The results showed t...

Background: Ofloxacin is a fluoroquinolone antibiotic very useful in the treatment of several bacterial infections. The Thiazolidinone ring system represents privileged structure drug discovery. multi-drug-resistant tuberculosis bacteria infects many people worldwide and disease kills 1.8 million annually, so combination ofloxacin-thiazolidinone ...

A series of 4-Thiazolidinone derivatives were synthesized by reaction of 3-formyl-2-arylindole derivatives, 2aminonaphthaline and mercaptoacetic acid. The structures of the new compounds were assigned on the basis of their analytical and spectral data.