STUDY OBJECTIVE To compare the efficacy, tolerability, and safety of therapy with formoterol and oral slow-release theophylline (THEO) in patients with COPD. DESIGN A randomized, parallel-group study, with double-blind arms for formoterol and placebo (PL) and an open arm for oral slow-release THEO administered in individual doses on the basis of plasma concentrations. SETTING Eighty-one cen...

We survey the basics of homological algebra in exact categories in the sense of Quillen. All diagram lemmas are proved directly from the axioms, notably the five lemma, the 3×3-lemma and the snake lemma. We briefly discuss exact functors, idempotent completion and weak idempotent completeness. We then show that it is possible to construct the derived category of an exact category without any em...

BACKGROUND Expert-based genotypic interpretation systems are standard methods for guiding treatment selection for patients infected with human immunodeficiency virus type 1. We previously introduced the software pipeline geno2pheno-THEO (g2p-THEO), which on the basis of viral sequence predicts the response to treatment with a combination of antiretroviral compounds by applying methods from stat...

The past decade has witnessed ground-breaking advances in human stem cell biology with scientists validating adult neurogenesis and establishing methods to isolate and propagate stem cell populations suitable for transplantation. These advances have forged promising strategies against human neurodegenerative diseases. For example, growth factor administration could stimulate intrinsic repair fr...

I argue that to the extent to which philosophical theories of objective probability have offered theoretically adequate conceptions of objective probability (in connection with such desiderata as causal and explanatory significance, applicability to single cases, etc.), they have failed to satisfy a methodological standard roughly, a requirement to the effect that the conception offered be spec...

Resolution of binary mixtures of theophylline (THEO), montelukast (MKST) and loratadine (LORA) with minimum sample pretreatment and without analyte separation has been successfully achieved by multivariate spectrophotometric calibration, together with partial least-squares (PLS-1), principal component regression (PCR) and hybrid linear analysis (HLA). Data of analysis were obtained from UV–Vis ...

The objective of the present study was to determine if patients with COPD who were taking Theo-Dur bid or tid (total dose 400 to 900 mg per day) could be safely switched to Uni-Dur, 800 mg given qd at bedtime. Twenty-eight patients were enrolled in the study, and 23 completed the study. The mean daily dose of theophylline prior to the study was 828 mg, while the mean dose after three weeks of U...

Theodora Colborn, research scientist and environmental activist, died 14 December 2014 at the age of 87. As the scientist who coined the term “endocrine disruptor,” Theo—as we had the privilege to call her—played a watershed role in the field of environmental health science, particularly in raising public awareness of the effects of chemical contaminants on human health and the environment. It ...