نتایج جستجو برای: thalassemia carrier rate
تعداد نتایج: 1042539 فیلتر نتایج به سال:
background: iran is one of the countries located on “the thalassemia belt” with a significant annual number of thalassemia new births. given the importance of thalassemia prevention, a program to this effect was approved in iran in 1995. screening of carrier couples and prenatal diagnosis were the two main elements of this program. in the present study, the authors have tried to address the imp...
Background: Iran is one of the countries located on “the thalassemia belt” with a significant annual number of thalassemia new births. Given the importance of thalassemia prevention, a program to this effect was approved in Iran in 1995. Screening of carrier couples and prenatal diagnosis were the two main elements of this program. In the present study, the authors have tried to address the imp...
background and objectives: beta-thalassemia continues to be a cause of significant burden to the society particularly in the poorer developing countries. although sophisticated methods of screening have become available, a hunt for a cheap, rapid, objective screening method still remains elusive. thus, the objectives are to study the validity of naked-eye-single-tube-osmotic-fragility-test (nes...
Background & Aims of the Study: Since beta-thalassemia is the most commonly inherited disease in Iran, its preventive and controlling programs are considered vitally important in the healthcare system. This study was conducted to investigate the incidence rate and epidemiology of major beta-thalassemia (MBT) over the last twenty years in Kerman, Iran. Materials and Methods: This cross-secti...
The haemoglobinopathies and thalassemias represent the most common inherited monogenic disorders in the world. Beta-thalassaemia major is an ongoing public health problem in Malaysia. Prior to 2004, the country had no national policy for screening and registry for thalassemia. In the absence of a national audit, the true figure of the extent of thalassemia in the Malaysian population was largel...
OBJECTIVE To reveal the familial prevalence and molecular variation of α- and β-globin gene mutations in Guangdong Province. METHODS A total of 40,808 blood samples from 14,332 families were obtained and analyzed for both hematological and molecular parameters. RESULTS A high prevalence of α- and β-globin gene mutations was found. Overall, 17.70% of pregnant women, 15.94% of their husbands,...
BACKGROUND It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese population. METHODS 230 newborns' dried blood cards remaining from routine neonat...
Objective(s): Iran is considered as one of the high-prevalence areas for β-thalassemia with a rate of about 10% carrier frequency. Molecular diagnosis of the disease is performed both by direct sequencing and indirectly by the use of polymorphic markers present in the beta globin gene cluster. However, to date there is no reliable information on the application of the markers in the Iranian pop...
background and purpose: despite extensive research on family planning and education, reproductive behavior of high-risk couples for thalassemia remains a major concern among medical professionals. this study aimed to evaluate the knowledge and attitude of carrier couples for transfusion-dependent thalassemia major (tdtm). methods: this case-control study was conducted 327 carrier couples for th...
Thalassemia is a genetic blood disorder that causes abnormal hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen and is made of two proteins from four α-globin genes and two β-globin genes. A defect in one or more of these genes causes thalassemia. The treatment of thalassemia mostly depends on life-long blood transfusions and removal of excessive iron from the blood stre...
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