background t-helper (th) lymphocyte cytokine production may be important in the immune pathogenesis of hepatitis c virus (hcv) infections. th1 cytokines such as; interleukin- 2 (il-2), and interferon gamma (ifn-gamma) are necessary for host antiviral immune responses, while th2 cytokines (il-4, il-10) can inhibit the development of these effector mechanisms. objectives the aim of the present st...

objective: dendritic cells (dcs) play a critical role in the beginning and in the course of immune responses. by observing. considering the defect in these cells in patients with tumor malignancy. in recent years there has been considerable interests in correction and use of these cells. in our prvious studies we showed that lysate of listeria monocytogenese can induce maturation of dendritic c...

Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF and play an important role in the increase of delaying sensitivity and defense against intracellular pathogens. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages,enhancing phagocytosis, and also increasing MHC class I and class II mo...

Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...

coronary  atherosclerotic  disease  is  one  of  the  most  endangering  health  disorder worldwide. this study was designed to investigate the correlation between hla-drβ1 alleles and circulating th1/th2 type cytokines in coronary atherosclerosis. by elisa, th1/th2 type cytokines were determined in serum samples of 31 subjects with unstable angina, 27 subjects with chronic stable angina and 24...

activated macrophages have been classified into classical (m1) and alternative (m2) macrophages. we aimed to establish a method to yield enough number of macrophages to analyze their molecular, biological and immunological functions. we used drugs; adjuvant albumin from chicken egg whites—imject alum (ova- alum) and ova complete freund adjuvant (ova-cfa), to induce macrophages to m2 and m1 resp...

there are limited clinical investigations identifying the percentage of t helper 1 (th1) and t regulatory (treg) cells in stable as well as rejected kidney allografts, a concept which needs to be more studied. the aim of our study was to compare the percentage of cd4+ ifn-γ+ cells, the number of ifn-γ secreting cells and the amount of foxp3 expression in patients with or without stable graft fu...

Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...