نتایج جستجو برای: th1
تعداد نتایج: 15003 فیلتر نتایج به سال:
Emerging T-helper type 2 (Th2 ) cytokine-based asthma therapies, such as tralokinumab, lebrikizumab (anti-interleukin (IL)-13), and mepolizumab (anti-IL-5), have shown differences in their blood eosinophil (EOS) response. To better understand these effects, we developed a mathematical model of EOS dynamics. For the anti-IL-13 therapies, lebrikizumab and tralokinumab, the model predicted an incr...
Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages, enhancing phagocytosis, and also increasing MHC class I and class II molecules. Increasing serum level of Th1 cytokines have also been observed in MS patients. It has also been prov...
Th1 lymphocytes produce cytokines such as IL-2, IFN-γ, and TNF-α, TNF-β and GM-CSF and play an important role in the increase of delaying sensitivity and defense against intracellular pathogens. IFN-γ is the most important Th1 cell cytokine that induces the production of IgG, activation of macrophages,enhancing phagocytosis, and also increasing MHC class I and class II mo...
Objectives: to study the levels of total, phosphorylated p65-subunit nuclear factor NF-kB, activity p65 and relation with level ratio T-helpers type I II in pregnant women placental dysfunction different clinical types course preterm labor (with premature rupture membranes (pPROM) without it).Materials methods. The case-control included 60 women: 40 disorders spontaneous period 24–34 weeks (gro...
گروههای موشی با آنتی ژنهای rcaga+ cpg، lps + cpg،pbs و r caga+ lps + cpg سه بار از طریق خوراکی و دو بار از طریق داخل عضلانی طی فواصل 10 روزه ایمن شدند. پاسخ های اختصاصی اینترفرون گاما، اینترلوکین 4، اینترلوکین 10و tgf? در طحال موش های ایمن شده بعد از مواجهه با سویه ss1 با روش الایزا اندازه گیری شد.میزان کشندگی لیپو پلی ساکارید هلیکوباکتر پیلوری نسب به e. coli و بروسلا کمتر بود. میزان توکسیسیته ...
سلول هایt در پاتوژنز دیابت نوع یک نقش مهمی را بازی می کنند، هر چند که نقش دقیق زیرجمعیتهای سلولی مولد آن تاکنون شناسایی نشده است. با این حال عدم تعادل بین پاسخ سلولی th1 و th2 در روند ایجاد و گسترش این بیماری خود ایمن به اثبات رسیده است. در این مطالعه ارتباط تغییرات بیان فاکتورهای رونویسی t-bet و gata-3 که به ترتیب فاکتورهای پیش برنده تمایزسلول های th1، که منبع اصلی تولیدکنندهifn-? هستند،و سلول...
objective: dendritic cells (dcs) play a critical role in the beginning and in the course of immune responses. by observing. considering the defect in these cells in patients with tumor malignancy. in recent years there has been considerable interests in correction and use of these cells. in our prvious studies we showed that lysate of listeria monocytogenese can induce maturation of dendritic c...
Background and purpose: CD4+CD25+FOXP3+ regulatory T cells (CD4+CD25+FOXP3+ Tregs) are a group of T lymphocytes that play an important role in regulating immune system responses by suppressing the activity of other T cells and establishing homeostasis in the immune system. Th1 and Th2 cells are other groups of CD4+ cells that play important functions in inducing inflammatory immune responses. C...
The role of CD28/B7 and LFA-1/ICAM costimulation in proliferation and Th1/Th2 differentiation of naive CD4+ T cells was addressed using T cells from DO11.10 TCR transgenic mice stimulated by dendritic cells. The blockade of either CD28/B7 or LFA-1/ICAM interactions partially inhibited T cell proliferation. By comparison, blocking CD28/B7 costimulation inhibited IL-4 and IL-5 (Th2 cytokine) prod...
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