TGF-b1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-b1 induces apoptosis; VEGF induces survival. We have previously shown that TGF-b1 induces endothelial cell expression of VEGF, which mediates TGF-b1 induction of apoptosis through activation of p38mitogen-activated protein kinase (MAPK). Because VEGF activates p38 but protects the cells from ap...

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Self-assembling peptide hydrogels were modified to deliver transforming growth factor b1 (TGF-b1) to encapsulated b...

GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-b1. We find that GARP and latent TGF-b1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL...

OBJECTIVE To investigate the role of TGF-b1 in autophagy and invasion ability in human gastric carcinoma cell line SGC7901. MATERIALS AND METHODS Cultured SGC7901 cells were treated with different concentrations of TGF-b1 for 24 h. The protein expression levels of autophagy relative marker LC3 and Beclin1 were detected by Western blot. The effect of TGF-b1 on invasion ability of SGC7901 cells...

Transforming growth factor-b1 (TGF-b1), a multifunctional cytokine with fibrogenic properties, has been implicated in the pathogenesis of the vascular and target organ complications of hypertension. TGF-b1 may also regulate blood pressure via stimulation of endothelin-1 and/or renin secretion. Herein we explored the hypothesis that circulating levels of TGF-b1 protein (quantified using a TGF-b1...

Background: The TGF-b signaling pathway is crucial in the progression and metastasis of malignancies. We investigated whether the serum TGF-b1 level was related to the outcomes of patients treated with sorafenib for advanced hepatocellular carcinoma (HCC). Experimental Design: We selected patients who had received sorafenib-containing regimens as first-line therapy for advanced HCC between 2007...

Transforming growth factor-b1 (TGF-b1) is expressed in the adult and embryonic vasculature; however, the biological consequences of increased vascular TGF-b1 expression remain controversial. To establish an experimental setting for investigating the role of increased TGF-b1 in vascular development and disease, we generated transgenic mice in which a cDNA encoding a constitutively active form of...

Fong, Choong Yi, Linhua Pang, Elaine Holland, and Alan J. Knox. TGF-b1 stimulates IL-8 release, COX-2 expression, and PGE2 release in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 279: L201–L207, 2000.—We have recently shown that endogenous prostanoids are critical in bradykinin-stimulated interleukin (IL)-8 release from human airway smooth muscle (ASM) cells. In this stu...