نتایج جستجو برای: tetramisole
تعداد نتایج: 46 فیلتر نتایج به سال:
1. Tetramisole (100 mug/ml) paralysed live Ascaris in 3 min.2. Tetramisole (10 mug/ml) caused a sustained contraction of the isolated somatic muscles of the worm. This contraction was not blocked by curare nor by piperazine.3. Tetramisole reduced the resting potential of Ascaris muscle from 34+/-4 to 10+/-1 mV.4. Tetramisole caused contraction of Ascaris muscle previously depolarized with high ...
Tetramisole, a new synthetic anthelmintic, was compared with piperazine in the treatment of ascariasis in African children. Of 100 children receiving tetramisole 94 were cured, and of 100 given piperazine 85 were cured (0.05>P>0.02). Tetramisole was free of side-effects.
Alkaline phosphatase has been implicated in matrix vesicle-mediated calcification. We sought to clarify its role in this process by studying the effect of L-tetramisole, a strong uncompetitive inhibitor of this enzyme, and D-tetramisole, its inactive isomer, on the uptake of 32Pi and 45Ca by matrix vesicle-enriched microsomes obtained from chicken epiphyseal cartilage. Uptake of both 32Pi and 4...
Received: 22/01/2014 Revised: 27/02/2014 Accepted: 02/03/2014 Abstract A study was conducted to determine and compare the efficacy of fenbendazole and oxyclozanide-tetramisole combination against gastrointestinal nematodes in naturally infected Gaddi goats. On treatment, both the groups i.e. fenbendazole at 7.5 mg / kg body weight and oxyclozanide-tetramisole combination at 1 ml / 3 kg body wei...
The aim of this work is to develop and validate simple, sensitive, selective and cost effective spectrophotometric methods for the determination of tetramisole hydrochloride in the presence of its alkali-induced degradation product without preliminary separation. These methods namely ratio difference [11,12], derivative ratio [13,14], mean centering [15,16] and continuous wavelet transform [17,...
Levamisole (the laevorotatory isomer of tetramisole) is a new synthetic anthelmintic. A cure rate of 91% was obtained in a series of 111 ascariasis-infected children treated with a single oral dose of the drug. The failures, who were treated with the drug a second time one week later, were all cured. In a comparative study of levamisole and piperazine citrate in a series of 100 children with as...
The aim of this work is to develop and validate simple, sensitive, selective and cost effective spectrophotometric methods for the determination of tetramisole hydrochloride in the presence of its alkali-induced degradation product without preliminary separation. These methods namely ratio difference [11,12], derivative ratio [13,14], mean centering [15,16] and continuous wavelet transform [17,...
The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diast...
BACKGROUND Gastrointestinal nematode (GIN) infections are the main impediments that restrict the welfare and productivity of small ruminant in the world. Effective management of GINs in grazing sheep relies heavily on the use of highly efficacious anthelmintic drugs. However, anthelmintic resistance is becoming a significant concern in the world, and this phenomenon severely threatens the poten...
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