limb bud first appears during the third week of gestation with the upper limb buds appearing a few days before the lower limb buds. complete absence of one or more limbs, called amelia, occurs prior to the eighth week of gestation. we report a case of amelia in a twin gestation.

A gravid middle-aged woman viewed on ultrasound demonstrated a viable anencephalic fetus at 25 weeks gestational age. The absence of the bilateral cerebral hemisphere, cranial vault, anhydramnios, abdominal ascites, and phaco-rhizomelia was discovered. We discuss evidence-based quadra –amelia in non-consanguineous (negroid) couple 25-week prenatal scan. Apart from amelia all four limbs, had asc...