نتایج جستجو برای: tetrahydropyridazine
تعداد نتایج: 12 فیلتر نتایج به سال:
The gold-catalyzed [3+3]-cycloaddition reaction of propargyl esters and azomethine imines has been developed. The reaction provides a rapid entry into a wide range of substituted tetrahydropyridazine derivatives from simple starting materials. A stepwise mechanism involving addition of the 1,3-dipole to a gold-carbenoid intermediate is proposed.
The design and solid-phase synthesis of tetrahydropyridazine-3,6-dione (Tpd) peptidomimetics derived from backbone-aminated peptides is reported. The described protocol features the synthesis of chiral α-hydrazino acids suitable for chemoselective incorporation into growing peptide chains. Acid-catalyzed cyclization to form the Tpd ring during cleavage affords the target peptidomimetics in good...
Herein we report saturated and unsaturated fatty acid derivatives of 1,3,4-oxadiazol-2(3H)-one and tetrahydropyridazine-3,6-dione as new potential anticancer agents. All the synthesised compounds were characterised by IR, (1)H-NMR, (13)C-NMR, and mass spectral data. The relative sensitivity of three cancer cell lines varied depending on the nature of the compound. Among the most effective antic...
Abstract The conversion of benzophenone methylhydrazone with bromine and pyridine into 1-[(methyldiazenyl)diphenylmethyl]pyridin-1-ium bromide followed by the solvolysis methanol provides a facile synthesis 1-(methoxydiphenylmethyl)-2-methyldiazene. acid-induced hydrolysis this N,O-ketal releases methyldiazenyl moiety as putative intermediate methyldiazenium ion. Reacting heterodienophile, ion ...
The aim of this study was to synthesize a new oxetan-phenyltetrahydropyridazine-3,6-dione derivative (compound 6) using with different techniques. The first method was achieved by the preparation of a phenylhydrazine derivative (2) using three components system (3,17-aldol-estradiol, phenylhydrazine, 5-hexyn-3-ol) in presence of Copper(II). Then, 2 Was reacted with tert-butyldimethylsilyl chlor...
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