Synthetic cannabinoids (SC) are a heterogeneous group of substances with a high affinity for cannabinoid receptors. Unlike Δ9-tetrahydrocannabinol (THC), synthetic cannabinoids are incredibly potent, highly productive, have more affinity for the Cannabinoid receptor type 1 (CB1), and Cannabinoid receptor type 2 (CB2), and are designed to accelerate the effects of tetrahydrocannabinol. Also, the...

cannabis is one of the most widely abused substances throughout the world. the primary psychoactive constituent of cannabis, delta 9-tetrahydrocannabinol (▵(9_)thc), produces a myriad of pharmacological effects in animals and humans. although it is used as a recreational drug, it can potentially lead to dependence and behavioral disturbances and its heavy use may increase the risk for psychotic...

1. delta9-Tetrahydrocannabinol and cannabidiol both exhibited a concentration-related inhibition of Mg2+-ATPase of vesicles prepared from synaptosomes isolated from rat cerebral cortex. Cannabidiol was about 3 times more potent than tetrahydrocannabinol. 2. These results were similar to those obtained previously using drugs with well established anticonvulsant activity. 3. Tetrahydrocannabinol ...

Plasma concentrations of delta-9-tetrahydrocannabinol, the principal psychoactive cannabinoid in marijuana, decline to values substantially less than 1 microgram/L within a few hours after a subject has smoked a marijuana cigarette. Using a single-quadrupole gas chromatograph-mass spectrometer (GC/MS) operated in the negative chemical-ionization mode and retrofitted with a High Energy Dynode de...

The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol was reduced in mutant mice, whereas no difference between genotypes was observed in the effects induced on body temperature, locomotion, or ring catalepsy. During a chronic tr...

objective(s): the object of the study is to examine the effects of δ9-tetrahydrocannabinol (thc) against oxidative stress in the blood and excretion of thc metabolites in urine of type 2 diabetic rats. materials and methods: the control (n=8), thc control (n=6), diabetes (n=8) and diabetes + thc (n=7) groups were created. type 2 diabetes was induced by nicotinamide (na, 85 mg/kg) + streptozotoc...

BACKGROUND Δ(9)-Tetrahydrocannabinol has been shown to modulate anxiety and facilitate the extinction of fear by inhibiting amygdala reactivity. Since functional coupling between the amygdala and prefrontal cortex is implicated in affective processes, it is possible that Δ(9)-tetrahydrocannabinol affects amygdala-prefrontal cortex functional connectivity in ways that differ across amygdala subr...

BACKGROUND Chronic neuropathic pain affects 1%-2% of the adult population and is often refractory to standard pharmacologic treatment. Patients with chronic pain have reported using smoked cannabis to relieve pain, improve sleep and improve mood. METHODS Adults with post-traumatic or postsurgical neuropathic pain were randomly assigned to receive cannabis at four potencies (0%, 2.5%, 6% and 9...

From several studies it has been shown, that ∆-tetrahydrocannabinolglucuronide is a phase II metabolite of ∆-tetrahydrocannabinol (THC) formed and excreted in urine in humans [1]. There is not much known either about the extent of glucuronidation in the metabolic degradation and elimination of ∆tetrahydrocannabinol (THC) or about which one of the enzymes of the UDPGlucuronosyl-Transferase (UGT)...