background:  matricaria chamomilla is an ancient herbal drug widely consumed to sexual system improvement. the aim of this research was to study the effect of matricaria chamomilla hydroalcholic extract on the pituitary-testis axis and testes tissues of male rats. methods:  mature male rats were randomly assigned to two groups: the matricaria group (100 mg/kg of matricaria chamomilla extract vi...

the fact that the stress response affects testicular function in several animal species, has been established for several decades. the aim of the present review was to describe how the mechanisms involved in the acute stress response affect directly or indirectly the testicular function at different levels. Both neuroendocrine axes linked to the stress response, i.e., the sympathetic-adrenomedu...

AIM The pathogenesis of hypogonadism in liver cirrhosis is not well understood. Previous results from our laboratory showed that IGF-1 deficiency might play a pathogenetic role in hypogonadism of cirrhosis. The administration of IGF-1 for a short period of time reverted the testicular atrophy associated with advanced experimental cirrhosis. The aim of this study was to establish the historical ...

The pineal hormone melatonin regulates testicular function through the hypothalamic-adenohypophyseal axis. In addition, direct actions of melatonin in somatic cells of the testis have been described. Melatonin acts as a local modulator of the endocrine activity in Leydig cells. In Sertoli cells, melatonin influences cellular growth, proliferation, energy metabolism and the oxidation state, and ...

Testicular tumors and their treatment interfere with homeostasis, hormonal status included. The aim of the study was to evaluate hormonal disorders of the pituitary-gonadal axis in men treated for testicular tumors. One hundred twenty-eight men treated for a unilateral testicular tumor at our institution were included. The hormonal status was prospectively evaluated in 62 patients before orchie...

Testicular torsion is a common surgical emergency of adolescent males presenting with sudden onset of intense scrotal pain. Anatomically testicular torsion follows a congenital anomaly in predisposed individuals that allows the testis to rotate, twisting the spermatic cord, resulting in loss of blood supply and eventual testicular necrosis. The most common underlying cause is a congenital malfo...

Testicular torsion is a common surgical emergency of adolescent males presenting with sudden onset of intense scrotal pain. Anatomically testicular torsion follows a congenital anomaly in predisposed individuals that allows the testis to rotate, twisting the spermatic cord, resulting in loss of blood supply and eventual testicular necrosis. The most common underlying cause is a congenital malfo...