multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

Cathepsin S (CS) is a lysosomal/endosomal cysteine protease especially expressed in cells of a mononuclear lineage including microglia. To better understand the role of CS in microglia, we investigated microglial responses after a facial nerve axotomy in CS-deficient (CS-/-) and wild-type mice. Microglia in both groups accumulated in the facial motor nucleus following axotomy. However, the mean...

Purpose: Tenascin is an extracellular matrix glycoprotein which is expressed transiently in wound healing in human skin and animal corneas. In virro and ednbryological studies suggest that tenascin mediates cell adhesion/anti-adhesion, enhancunen~mlubltion of cell proliiation, and promotion of cell migration. At present there are no published data regarding human comeal wound healing, therefore...

As a glycosphingolipid that can bind to several extracellular matrix proteins, sulfatide has the potential to become an effective targeting agent for tumors overexpressing tenasin-C in their microenvironment. To overcome the dose-limiting toxicity of doxorubicin (DOX), a sulfatide-containing nanoliposome (SCN) encapsulation approach was employed to improve treatment efficacy and reduce side eff...

Functional tissue engineering of connective tissues such as the anterior cruciate ligament (ACL) remains a significant clinical challenge, largely due to the need for mechanically competent scaffold systems for grafting, as well as a reliable cell source for tissue formation. We have designed an aligned, polylactide-co-glycolide (PLGA) nanofiber-based scaffold with physiologically relevant mech...

Purpose: Tenascin is an extracellular matrix glycoprotein which is expressed transiently in wound healing in human skin and animal corneas. In virro and ednbryological studies suggest that tenascin mediates cell adhesion/anti-adhesion, enhancunen~mlubltion of cell proliiation, and promotion of cell migration. At present there are no published data regarding human comeal wound healing, therefore...

Purpose: Tenascin is an extracellular matrix glycoprotein which is expressed transiently in wound healing in human skin and animal corneas. In virro and ednbryological studies suggest that tenascin mediates cell adhesion/anti-adhesion, enhancunen~mlubltion of cell proliiation, and promotion of cell migration. At present there are no published data regarding human comeal wound healing, therefore...

Optimal repair and adaptation of skeletal muscle is facilitated by resident stem cells (satellite cells). To understand how different exercise modes influence satellite cell dynamics, we measured satellite cell activity in conjunction with markers of muscle damage and inflammation in human skeletal muscle following a single work- and intensity-matched bout of eccentric (ECC) or concentric contr...

What is ECS and why is it important? rain tissue is essentially composed of two regions: cellular elements (neurons and glial cells), and the gap between the elements, which is known as the extra-cellular space (ECS; Figure 1) (Sykova & Nicholson, 2008). The ECS resembles the water phase of a foam and remains a highly connected domain even though it is convoluted in shape and may form dead-spac...