BACKGROUND Finding an effective treatment for acne that is well tolerated by the patients is a challenge. One study has suggested the efficacy of tea tree oil in treatment of the acne vulgaris. AIM To determine the efficacy of tea tree oil in mild to moderate acne vulgaris. METHODS This was a randomized double-blind clinical trial performed in 60 patients with mild to moderate acne vulgaris...

background: melaleuca alternifolia (tea tree) essential oil has been traditionally used in the ayurvedic system of medicine for healing burns, infections and seborrheic dermatitis. but yet, no controlled human study has determined its efficacy. objective: the goal of the current study was to compare the efficacy of 5% tea tree essential oil (tto) gel with placebo in the treatment of mild to mod...

OBJECTIVES The essential oil of Melaleuca alternifolia (tea tree oil) and its components have antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, fungi and viruses. The mechanism(s) by which Pseudomonas aeruginosa NCTC 10662 maintains a decreased susceptibility to tea tree oil and components was investigated. RESULTS Ethylene diamine tetraacetic acid enhan...

BACKGROUND Tea tree oil is the essential oil steam-distilled from Melaleuca alternifolia, an Australian native plant. In recent years it has become increasingly popular as an antimicrobial for the treatment of conditions such as tinea pedis and acne. OBJECTIVES To investigate the anti-inflammatory properties of tea tree oil on histamine-induced weal and flare. METHODS Twenty-seven volunteer...

OBJECTIVES The aim of this study was to investigate the mechanism of action of tea tree oil and its components against Candida albicans, Candida glabrata and Saccharomyces cerevisiae. METHODS Yeast cells were treated with tea tree oil or components, at one or more concentrations, for up to 6 h. During this time, alterations in permeability were assessed by measuring the leakage of 260 nm abso...

Background: Melaleuca alternifolia (tea tree) essential oil has been traditionally used in the ayurvedic system of medicine for healing burns, infections and seborrheic dermatitis. But yet, no controlled human study has determined its efficacy. Objective: The goal of the current study was to compare the efficacy of 5% tea tree essential oil (TTO) gel with placebo in the treatment of mild to m...

This study examined the effect of subinhibitory Melaleuca alternifolia (tea tree) essential oil on the development of antibiotic resistance in Staphylococcus aureus and Escherichia coli. Frequencies of single-step antibiotic-resistant mutants were determined by inoculating bacteria cultured with or without subinhibitory tea tree oil onto agar containing 2 to 8 times the MIC of each antibiotic a...

Tea tree oil has been shown to have activity against dermatophytes in vitro. We have conducted a randomized, controlled, double-blinded study to determine the efficacy and safety of 25% and 50% tea tree oil in the treatment of interdigital tinea pedis. One hundred and fifty-eight patients with tinea pedis clinically and microscopy suggestive of a dermatophyte infection were randomized to receiv...

Background: Candida species are an important cause of opportunistic infection in the oral cavity of immunocompromised patients. Various antifungal agents have been used for the treatment of oral candida infection. Tea tree oil is a herbal product which is known to have broad antifungal properties. Objective: To compare the antifungal efficacy of 1% tea tree oil, 1% clotrimazole, and 0.2% chlorh...

The in vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes (n = 106) and filamentous fungi (n = 78) was determined. Tea tree oil MICs for all fungi ranged from 0.004% to 0.25% and minimum fungicidal concentrations (MFCs) ranged from <0.03% to 8.0%. Time-kill experiments with 1-4 x MFC demonstrated that three of the four test organisms were still detected after 8 h of t...