نتایج جستجو برای: tdb

تعداد نتایج: 192  

2016
Mick Serpell Shiva Tripathi Sabine Scherzinger Sònia Rojas-Farreras Alexander Oksche Margaret Wilson

BACKGROUND Opioids provide effective analgesia for moderate-to-severe, chronic pain. Transdermal buprenorphine (TDB) is available in the UK as weekly, lower-dose (5-20 μg/h) patches and twice-weekly, higher dose (35-70 μg/h) patches. This prospective, observational, multicenter study of patients with various chronic pain conditions assessed the safety, perceptions, and discontinuation of treatm...

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2016
Philip G. Conaghan Michael Serpell Paula McSkimming Rod Junor Sara Dickerson

BACKGROUND Osteoarthritis (OA) causes substantial pain and reduced health-related quality of life (HRQL). Although opioid analgesics are commonly used, the relative benefits of different opioids are poorly studied. Transdermal buprenorphine (TDB) offers an alternative to oral opioids for the treatment of moderate-to-severe chronic pain. This observational study of people with OA pain assessed s...

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2017
Kristel Kodar Jacquie L Harper Melanie J McConnell Mattie S M Timmer Bridget L Stocker

INTRODUCTION Macrophages play a significant role in the progression of diseases, such as cancer, making them a target for immune-modulating agents. Trehalose dibehenate (TDB) is known to activate M1-like macrophages via Mincle, however, the effect of TDB on M2-like macrophages, which are found in the tumor microenvironment, has not been studied. METHODS qRT-PCR, flow cytometry, cytokine ELISA...

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Journal: :Cancer research 2014
Teemu T Junttila Ji Li Jennifer Johnston Maria Hristopoulos Robyn Clark Diego Ellerman Bu-Er Wang Yijin Li Mary Mathieu Guangmin Li Judy Young Elizabeth Luis Gail Lewis Phillips Eric Stefanich Christoph Spiess Andrew Polson Bryan Irving Justin M Scheer Melissa R Junttila Mark S Dennis Robert Kelley Klara Totpal Allen Ebens

Clinical results from the latest strategies for T-cell activation in cancer have fired interest in combination immunotherapies that can fully engage T-cell immunity. In this study, we describe a trastuzumab-based bispecific antibody, HER2-TDB, which targets HER2 and conditionally activates T cells. HER2-TDB specifically killed HER2-expressing cancer cells at low picomolar concentrations. Becaus...

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Journal: :Journal of immunology 2010
Hanne Schoenen Barbara Bodendorfer Kelly Hitchens Silvia Manzanero Kerstin Werninghaus Falk Nimmerjahn Else Marie Agger Steffen Stenger Peter Andersen Jürgen Ruland Gordon D Brown Christine Wells Roland Lang

The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM and TDB. The Syk-coupling adapter protein FcRgamma was essential for macrophage activati...

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Journal: :Environmental microbiology 2016
Kevin D Kohl Ashley Stengel M Denise Dearing

It has been hypothesized that herbivores host tannin-degrading bacteria (TDB) to overcome the toxic challenges posed by plant tannins. While TDB have been isolated from the guts of numerous mammals, their functional significance to their hosts has never been explicitly tested. We introduced TDB into lab rats, which do not host TDB, and measured host performance on tannin-rich diets. We first is...

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Journal: :Journal of immunology 2014
Hanne Schoenen Alexandra Huber Nada Sonda Stephanie Zimmermann Jonathan Jantsch Bernd Lepenies Vincenzo Bronte Roland Lang

Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, and its synthetic analog Trehalose-6,6-dibehenate (TDB) bind to the C-type lectin receptors macrophage-inducible C-type lectin (Mincle) and Mcl to activate macrophages. Genetically, the transcriptional response to TDB/TDM has been defined to require FcRγ-Syk-Card9 signaling. However, TDB/TDM-triggered kinase activation has not been ...

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Journal: :Remote Sensing 2017
Yoshio Awaya Tomoaki Takahashi

Airborne light detection and ranging (LiDAR) has been used for forest biomass estimation for the past three decades. The performance of estimation, in particular, has been of great interest. However, the difference in the performance of estimation between stem volume (SV) and total dry biomass (TDB) estimations has been a priority topic. We compared the performances between SV and TDB estimatio...

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Journal: :Anticancer research 2014
Chatchai Chaotham Varisa Pongrakhananon Boonchoo Sritularak Pithi Chanvorachote

BACKGROUND Anti-metastasis therapy may become the potential means of improving survival of cancer patients. As the ability of cancer cells to change phenotype from epithelial to mesenchymal has been recognized as an important hallmark of cancer metastasis, this study provides information regarding the effect of a bibenzyl, namely 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB), isolated from Den...

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Journal: :The journal of mathematics and computer science 2022

This paper introduces the notion of \(tdB\)-algebra, presents characteristics and properties dual \(B\)-filters \(B\)-subalgebras in a uniform topology on \(B\)-algebra terms its \(B\)-subalgebras. Moreover, this shows that \(B\)-structure is \(tdB\)-algebra.

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